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Takeda-6d

Name: Takeda-6d
Brand: TargetMol
SKU: T22436
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22436Cas No. 1125632-93-0

Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.

Takeda-6d

🥰Excellent

Purity: 98.27%

Catalog No. T22436Cas No. 1125632-93-0

Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.

Pack Size	Price	Availability
1 mg	$98	In Stock
2 mg	$137	In Stock
5 mg	$198	In Stock
10 mg	$297	In Stock
25 mg	$487	In Stock
50 mg	$678	In Stock
100 mg	$912	In Stock
200 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$269	In Stock

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Batch Information

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Purity:98.27%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.
Targets&IC50	VEGFR2:2.2 nM, Raf:7.0 nM

Chemical Properties

Molecular Weight	547.99
Formula	C₂₇H₁₉ClFN₅O₃S
Cas No.	1125632-93-0
Smiles	Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3n2)cc1NC(=O)c1cccc(c1Cl)C1(CC1)C#N
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (118.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8249 mL	9.1243 mL	18.2485 mL	91.2425 mL
5 mM	0.3650 mL	1.8249 mL	3.6497 mL	18.2485 mL
10 mM	0.1825 mL	0.9124 mL	1.8249 mL	9.1243 mL
20 mM	0.0912 mL	0.4562 mL	0.9124 mL	4.5621 mL
50 mM	0.0365 mL	0.1825 mL	0.3650 mL	1.8249 mL
100 mM	0.0182 mL	0.0912 mL	0.1825 mL	0.9124 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc