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Sodium Camptothecin

Name: Sodium Camptothecin
Brand: TargetMol
SKU: T40179
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40179Cas No. 25387-67-1

Sodium Camptothecin is a plant alkaloid with antitumor activity. Sodium Camptothecin is a reversible RNA synthesis inhibitor. Sodium Camptothecin is an effective adenovirus replication inhibitor. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA.

Sodium Camptothecin

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Purity: 98.93%

Catalog No. T40179Cas No. 25387-67-1

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$64	In Stock	In Stock
50 mg	$94	In Stock	In Stock
100 mg	$139	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.93%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sodium Camptothecin is a plant alkaloid with antitumor activity. Sodium Camptothecin is a reversible RNA synthesis inhibitor. Sodium Camptothecin is an effective adenovirus replication inhibitor. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA.
In vitro	Sodium Camptothecin (5 μM; 10 min) significantly inhibits heterogeneously sedimenting nuclear RNA (hnRNA) synthesis and disrupts ribosomal precursor RNA processing, allowing conversion of 45S RNA to 32S RNA but blocking the conversion of 32S RNA to 28S RNA [1].

Chemical Properties

Molecular Weight	389.36
Formula	C₂₀H₁₈N₂NaO₅
Cas No.	25387-67-1
Smiles	[Na+].CC[C@@](O)(C([O-])=O)c1cc2-c3nc4ccccc4cc3Cn2c(=O)c1CO
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (102.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5683 mL	12.8416 mL	25.6832 mL	128.4159 mL
5 mM	0.5137 mL	2.5683 mL	5.1366 mL	25.6832 mL
10 mM	0.2568 mL	1.2842 mL	2.5683 mL	12.8416 mL
20 mM	0.1284 mL	0.6421 mL	1.2842 mL	6.4208 mL
50 mM	0.0514 mL	0.2568 mL	0.5137 mL	2.5683 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	1.2842 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc