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lufenuron

Name: lufenuron
Brand: TargetMol
SKU: T5639
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5639Cas No. 103055-07-8

Alias Fluphenacur

Lufenuron (Fluphenacur) is a chitin-synthesis inhibitor.

lufenuron

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Purity: 99.87%

Catalog No. T5639Alias FluphenacurCas No. 103055-07-8

Lufenuron (Fluphenacur) is a chitin-synthesis inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$39	In Stock	In Stock
500 mg	$81	-	In Stock
1 g	$123	-	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

lufenuron AI Summary

lufenuron exhibits a broad spectrum of bioactivity, demonstrating inhibitory actions in various biological assays. It effectively inhibits Tau fibril formation, ROR gamma transcriptional activity, 15-human lipoxygenase, Menin-MLL interaction (relevant in MLL-related leukemias), Ubiquitin-specific Protease USP2a, USP1/UAF1, the antioxidant response element signaling pathway, human tyrosyl-DNA phosphodiesterase 1 (TDP1), the human pregnane X receptor (PXR) signaling pathway, human apurinic/apyrimidinic endonuclease 1 (APE1), and exhibits potential to block Ebola Virus entry. Additionally, it has demonstrated potency against schistosomiasis, evidenced through its activity in Schwann cell PMP22 intronic element assays. In insecticidal assays, lufenuron shows significant activity against 5th instar nymphs of Dysdercus koenigii, with an LD50 of 9.0 µg, and reduces the fertility of various fruit fly species including Anastrepha striata, Anastrepha obliqua, and Anastrepha serpentina by lowering egg hatching rates. Its toxicity towards red blood cells (RBCs) is relatively low, with an HC50 greater than 1000.0 µg mL^-1. However, it shows no significant antifungal effects, with MIC or GI values greater than 512.0 µg mL^-1 for various fungal strains. lufenuron displays potent inhibition of sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, with inhibition rates of 97.09% and 102.79% respectively at 10 µM. Antiviral activity was observed in inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells at a concentration of 10 µM (36.21% inhibition), though it showed low antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells and only a slight inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM (-2.546%). Lastly, lufenuron exhibited minimal inhibition of human HDAC6 in enzyme assays using both commercial and custom peptide substrates, with inhibition percentages of 2.46% and -1.65% respectively. These diverse bioactivities reflect its multifaceted potential across various biological pathways and diseases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lufenuron (Fluphenacur) is a chitin-synthesis inhibitor.
Synonyms	Fluphenacur

Chemical Properties

Molecular Weight	511.15
Formula	C₁₇H₈Cl₂F₈N₂O₃
Cas No.	103055-07-8
Smiles	FC(C(F)(F)F)C(F)(F)Oc1cc(Cl)c(NC(=O)NC(=O)c2c(F)cccc2F)cc1Cl
Relative Density.	1.631 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (53.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9564 mL	9.7819 mL	19.5637 mL	97.8186 mL
5 mM	0.3913 mL	1.9564 mL	3.9127 mL	19.5637 mL
10 mM	0.1956 mL	0.9782 mL	1.9564 mL	9.7819 mL
20 mM	0.0978 mL	0.4891 mL	0.9782 mL	4.8909 mL
50 mM	0.0391 mL	0.1956 mL	0.3913 mL	1.9564 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc