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Tolclofos-methyl

Name: Tolclofos-methyl
Brand: TargetMol
SKU: T5844
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5844Cas No. 57018-04-9

Tolclofos-methyl is an organophosphorus fungicide and widely utilized to control soil-borne diseases.

Tolclofos-methyl

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Purity: 98.37%

Catalog No. T5844Cas No. 57018-04-9

Tolclofos-methyl is an organophosphorus fungicide and widely utilized to control soil-borne diseases.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.37%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Tolclofos-methyl AI Summary

Tolclofos-methyl activates the Aryl hydrocarbon Receptor (AhR) signaling pathway with a potency of 79432.8 nM and the human pregnane X receptor (PXR) signaling pathway with a potency of 70794.6 nM. Additionally, this compound exhibits significant antifungal activity against various fungal species, including Fusarium oxysporum, Botrytis fabae, Pythium debaryanum, and Rhizoctonia solani. The effectiveness of Tolclofos-methyl varies with EC50 values of 51.3 µg/mL, 21.9 µg/mL, 8.9 µg/mL, and 5.7 µg/mL against these fungi, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Tolclofos-methyl is an organophosphorus fungicide and widely utilized to control soil-borne diseases.

Chemical Properties

Molecular Weight	301.13
Formula	C₉H₁₁Cl₂O₃PS
Cas No.	57018-04-9
Smiles	O(P(OC)(OC)=S)C1=C(Cl)C=C(C)C=C1Cl
Relative Density.	1.401 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (149.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3208 mL	16.6041 mL	33.2082 mL	166.0412 mL
5 mM	0.6642 mL	3.3208 mL	6.6416 mL	33.2082 mL
10 mM	0.3321 mL	1.6604 mL	3.3208 mL	16.6041 mL
20 mM	0.1660 mL	0.8302 mL	1.6604 mL	8.3021 mL
50 mM	0.0664 mL	0.3321 mL	0.6642 mL	3.3208 mL
100 mM	0.0332 mL	0.1660 mL	0.3321 mL	1.6604 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc