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ML328

🥰Excellent
Catalog No. T9678Cas No. 634175-34-1

ML328 is a potent and selective inhibitor of bacterial AddAB(IC50 = 1.0 μM) and RecBCD(IC50 = 4.8 μM) helicase-nucleases.

ML328

ML328

🥰Excellent
Purity: 99.71%
Catalog No. T9678Cas No. 634175-34-1
ML328 is a potent and selective inhibitor of bacterial AddAB(IC50 = 1.0 μM) and RecBCD(IC50 = 4.8 μM) helicase-nucleases.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$60In StockIn Stock
5 mg$147In StockIn Stock
10 mg$239In StockIn Stock
25 mg$455In StockIn Stock
50 mg$665In StockIn Stock
100 mg$928In StockIn Stock
200 mg$1,260In StockIn Stock
1 mL x 10 mM (in DMSO)$165In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.71%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
ML328 is a potent and selective inhibitor of bacterial AddAB(IC50 = 1.0 μM) and RecBCD(IC50 = 4.8 μM) helicase-nucleases.
Targets&IC50
RecBCD:4.8 μM, AddAB:1.0 μM
In vitro
The probe ML328 has a half-life of over 48 hours in PBS at room temperature when tested at 10 μM. Disappearance of the LC peak for the probe is unaltered by the addition of excess glutathione (50 μM) in a 6 hour incubation[1].
Chemical Properties
Molecular Weight506.5
FormulaC22H21F3N6O3S
Cas No.634175-34-1
SmilesC(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CN=C(N2)N3CCN(C(NC4=CC(C(F)(F)F)=CC=C4)=S)CC3
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (98.72 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9743 mL9.8717 mL19.7433 mL98.7167 mL
5 mM0.3949 mL1.9743 mL3.9487 mL19.7433 mL
10 mM0.1974 mL0.9872 mL1.9743 mL9.8717 mL
20 mM0.0987 mL0.4936 mL0.9872 mL4.9358 mL
50 mM0.0395 mL0.1974 mL0.3949 mL1.9743 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

RecBCD helicase-nucleaseML-328ML328ML 328AddAB helicase-nuclease
Related Tags: buy ML328 | purchase ML328 | ML328 cost | order ML328 | ML328 chemical structure | ML328 in vitro | ML328 formula | ML328 molecular weight
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