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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

3′,4′,7-Trihydroxyflavone 

🥰Excellent
Catalog No. TN3209Cas No. 2150-11-0

7,3',4'-Trihydroxyflavone inhibits osteoclastogenesis via the nuclear factor of activated T cells c1. 7,3',4'-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand-induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs).

3′,4′,7-Trihydroxyflavone 

3′,4′,7-Trihydroxyflavone 

🥰Excellent
Purity: 99.61%
Catalog No. TN3209Cas No. 2150-11-0
7,3',4'-Trihydroxyflavone inhibits osteoclastogenesis via the nuclear factor of activated T cells c1. 7,3',4'-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand-induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs).
Pack SizePriceAvailabilityQuantity
1 mg$108In Stock
5 mg$237In Stock
10 mg$352In Stock
25 mg$586In Stock
50 mg$835In Stock
100 mg$1,120In Stock
200 mg$1,490In Stock
1 mL x 10 mM (in DMSO)$219In Stock
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Purity:99.61%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
7,3',4'-Trihydroxyflavone inhibits osteoclastogenesis via the nuclear factor of activated T cells c1. 7,3',4'-Trihydroxyflavone can markedly inhibit the receptor activator of nuclear factor kappa B ligand-induced osteoclastic differentiation from mouse bone marrow-derived macrophages (BMMs).
Chemical Properties
Molecular Weight270.24
FormulaC15H10O5
Cas No.2150-11-0
SmilesOc1ccc2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Relative Density.1.548 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (203.52 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7004 mL18.5021 mL37.0041 mL185.0207 mL
5 mM0.7401 mL3.7004 mL7.4008 mL37.0041 mL
10 mM0.3700 mL1.8502 mL3.7004 mL18.5021 mL
20 mM0.1850 mL0.9251 mL1.8502 mL9.2510 mL
50 mM0.0740 mL0.3700 mL0.7401 mL3.7004 mL
100 mM0.0370 mL0.1850 mL0.3700 mL1.8502 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

RANKLp38MAPKp38 MAPKNuclear factor of activated Tcells (NFAT)NF-κBNFκBNF-kBNFkBInhibitorinhibitflavonoid aglyconbroad bean podsATPase3′,4′,7Trihydroxyflavone 3′,4′,7-Trihydroxyflavone3′,4′,7 Trihydroxyflavone 
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