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Anti-GPX4 Polyclonal Antibody
(Synonyms: snPHGPx, snGPx, PHGPx, NEDSGA, MCSP, GSHPx-4, GPx-4, GLURD, GLUR4C, GLUR4, GluA4) Copy Product Info
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Synonyms: snPHGPx, snGPx, PHGPx, NEDSGA, MCSP, GSHPx-4, GPx-4, GLURD, GLUR4C, GLUR4, GluA4
Catalog No. TMAB-00806 Copy Product Info
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Anti-GPX4 Polyclonal Antibody is a Rabbit antibody targeting GPX4. Anti-GPX4 Polyclonal Antibody can be used in WB.
Anti-GPX4 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-GPX4 Polyclonal Antibody is a Rabbit antibody targeting GPX4. Anti-GPX4 Polyclonal Antibody can be used in WB. |
| Synonyms | snPHGPx, snGPx, PHGPx, NEDSGA, MCSP, GSHPx-4, GPx-4, GLURD, GLUR4C, GLUR4, GluA4 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Pig,Cow,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm. |
| Tissue Specificity | Present primarily in testis. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site. |
| Immunogen | KLH conjugated synthetic peptide: human Glutathione Peroxidase 4 |
| Antigen Species | Human |
| Gene Name | GPX4 |
| Gene ID | |
| Protein Name | phospholipid hydroperoxide glutathione peroxidase |
| Uniprot ID | |
| Biology Area | Cellular metabolic process,Mitochondrial markers,Antioxidants,Cancer,Mitochondrial |
| Function | Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. |
| Molecular Weight | Theoretical: 22 kDa. Actual: 20-22 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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