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NMDI14
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Catalog No. T12235 Copy Product Info
Purity: 99.37%
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NMDI14 is a highly specific, small-molecule, non-competitive inhibitor of the nonsense-mediated RNA decay (NMD) pathway with an IC₅₀ value of 1.8 μM. NMDI14 can be used for studying NMD pathway function, PTC-related genetic disorders, and tumor research.
Cas No. 307519-88-6
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $32 | In Stock | In Stock | |
| 5 mg | $72 | In Stock | In Stock | |
| 10 mg | $128 | In Stock | In Stock | |
| 25 mg | $263 | In Stock | In Stock | |
| 50 mg | $396 | In Stock | In Stock | |
| 100 mg | $596 | - | In Stock | |
| 200 mg | $847 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $80 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.37%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NMDI14 is a highly specific, small-molecule, non-competitive inhibitor of the nonsense-mediated RNA decay (NMD) pathway with an IC₅₀ value of 1.8 μM. NMDI14 can be used for studying NMD pathway function, PTC-related genetic disorders, and tumor research. |
| In vitro | Methods: Human CRC cells: DLD1, RKO (MSI-H); SW480, SW620 (MSS) were treated with NMDI14 (10 μM) for 24 h. mRNA levels of classic NMD target genes (BAG1, GAS5, ATF4) were detected by qRT-PCR. Results: NMDI14 treatment significantly upregulated NMD target gene expression in all tested cell lines, confirming its effective inhibition of NMD. [1] |
| In vivo | Methods: MC38 cells were subcutaneously inoculated into C57BL/6J mice. Following successful inoculation, NMDI14 (10 mg/kg) was administered via intraperitoneal injection every other day for 23 days. Tumor volume and weight were monitored, and tumor-infiltrating immune cells were analyzed by flow cytometry. Results: In C57BL/6J mice, NMDI14 significantly inhibited tumor growth and increased CD8⁺ T cell, DC, and NK cell infiltration along with IFN-γ levels.[1] |
| Molecular Weight | 415.51 |
| Formula | C21H25N3O4S |
| Cas No. | 307519-88-6 |
| Smiles | CCOC(=O)c1c(C)c(C)sc1NC(=O)CC1Nc2cc(C)c(C)cc2NC1=O |
| Relative Density. | 1.250 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble), Sonication is recommended.  |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Related Tags: NMDI14 chemical structure | NMDI14 in vivo | NMDI14 in vitro | NMDI14 formula | NMDI14 molecular weight
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