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Anti-Cytochrome b245 Light Chain Polyclonal Antibody is a Rabbit antibody targeting Cytochrome b245 Light Chain. Anti-Cytochrome b245 Light Chain Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $221 | 7-10 days | |
100 μL | $372 | 7-10 days | |
200 μL | $529 | 7-10 days |
Description | Anti-Cytochrome b245 Light Chain Polyclonal Antibody is a Rabbit antibody targeting Cytochrome b245 Light Chain. Anti-Cytochrome b245 Light Chain Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
Alias | Superoxide-generating NADPH oxidase light chain subunit, p22-phox, p22phox, p22 phagocyte B-cytochrome, Neutrophil cytochrome b 22 kDa polypeptide, Flavocytochrome b 558 alpha polypeptide, Cytochrome b558 subunit alpha, Cytochrome b(558) alpha subunit, Cytochrome b(558) alpha chain, Cytochrome b alpha polypeptide, Cytochrome b 245 light chain, Cytochrome b 245 alpha polypeptide, CYBA, CY24A |
Ig Type | IgG |
Reactivity | Human,Mouse (predicted:Rat) |
Verified Activity | Tissue/cell: human liver carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Incubation: Anti-CYBA Polyclonal Antibody, Unconjugated (TMAB-00530) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining. |
Application | |
Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Cell Membrane |
Construction | Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Research Background | Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane, where they associate with the flavocytochrome cytochrome b558 to form the active enzyme complex. The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. |
Immunogen | KLH conjugated synthetic peptide: human CK18 Cytochrome b245 Light Chain/p22phox |
Antigen Species | Human |
Gene ID | |
Uniprot ID | |
Biology Area | Cellular metabolic process,Oxidative Stress,Cytotoxic Cells,Cytochromes,Oxidative stress |
Molecular Weight | Theoretical: 21 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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