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Alvelestat

Name: Alvelestat
Brand: TargetMol
SKU: T3107
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3107Cas No. 848141-11-7

Alias AZD9668, Avelestat

Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity.

Alvelestat

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Purity: 99.45%

Catalog No. T3107Alias AZD9668, AvelestatCas No. 848141-11-7

Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
2 mg	$38	In Stock	In Stock
5 mg	$54	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$159	In Stock	In Stock
50 mg	$243	In Stock	In Stock
100 mg	$387	In Stock	In Stock
500 mg	$923	-	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.45%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Alvelestat (AZD9668) is an orally bioavailable, selective, and reversible inhibitor of human neutrophil elastase (NE), exhibiting potential anti-inflammatory activity.
Targets&IC50	Neutrophil elastase:12 nM, Neutrophil elastase:9.4 nM(Ki)
In vitro	In a mouse model of (smoke)-induced airway inflammation, AZD9668 significantly reduced the number of (neutrophils) in the bronchoalveolar lavage (BAL) and the level of BAL IL-1β. Oral administration of AZD9668 in both mice and rats was able to inhibit (NE)-induced lung injury.
In vivo	In whole blood stimulated by yeast polysaccharide, AZD9668 effectively inhibits NE (NE) activity in the supernatant of antigen-challenged cells and on the surface of stimulated polymorphonuclear cells.
Synonyms	AZD9668, Avelestat

Chemical Properties

Molecular Weight	545.53
Formula	C₂₅H₂₂F₃N₅O₄S
Cas No.	848141-11-7
Smiles	Cc1c(cc(C(=O)NCc2ccc(cn2)S(C)(=O)=O)c(=O)n1-c1cccc(c1)C(F)(F)F)-c1ccnn1C
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 40 mg/mL (73.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8331 mL	9.1654 mL	18.3308 mL	91.6540 mL
5 mM	0.3666 mL	1.8331 mL	3.6662 mL	18.3308 mL
10 mM	0.1833 mL	0.9165 mL	1.8331 mL	9.1654 mL
20 mM	0.0917 mL	0.4583 mL	0.9165 mL	4.5827 mL
50 mM	0.0367 mL	0.1833 mL	0.3666 mL	1.8331 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc