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Ostruthin
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Catalog No. T125801Cas No. 148-83-4
Alias Ostruthine
Ostruthin (Ostruthine) is a natural coumarin with antimicrobial activity that can effectively inhibit the growth of a wide range of mycobacteria with a minimum inhibitory concentration of MIC= 3.4-107.4 μM.
Ostruthin
😃Good
Catalog No. T125801Alias OstruthineCas No. 148-83-4
Ostruthin (Ostruthine) is a natural coumarin with antimicrobial activity that can effectively inhibit the growth of a wide range of mycobacteria with a minimum inhibitory concentration of MIC= 3.4-107.4 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Ostruthin (Ostruthine) is a natural coumarin with antimicrobial activity that can effectively inhibit the growth of a wide range of mycobacteria with a minimum inhibitory concentration of MIC= 3.4-107.4 μM. |
| Targets&IC50 | DNA synthesis (rat aortic VSMCs, BrdU assay):17 μM, Serum-induced proliferation (rat aortic VSMCs, resazurin assay):11 μM |
| In vitro | Ostruthin exhibits potent antiproliferative activity against vascular smooth muscle cells (VSMCs) in vitro. In rat aortic VSMCs, ostruthin inhibited 10% serum-induced proliferation with an IC₅₀ of 11 ± 2 μM (resazurin assay) and suppressed DNA synthesis with an IC₅₀ of 17 ± 6 μM (BrdU assay). No significant cytotoxicity was observed at active concentrations (≤30 μM, cell viability >92%)[1]. |
| In vivo | Ostruthin, administered intraperitoneally at 5 mg/kg in ovariectomized female rats, significantly increased core body temperature within 30 minutes, with effects lasting over 3 hours. This thermogenic effect was observed regardless of progesterone treatment and is likely mediated by activation of TREK1/2 potassium channels, suggesting Ostruthin's potential for alleviating low body temperature symptoms in postmenopausal women[2]. |
| Synonyms | Ostruthine |
| Molecular Weight | 298.38 |
| Formula | C19H22O3 |
| Cas No. | 148-83-4 |
| Smiles | C(/C=C(/CCC=C(C)C)\C)C=1C=C2C(=CC1O)OC(=O)C=C2 |
| Storage | keep away from moisture,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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