Anti-SCAP Polyclonal Antibody is a Rabbit antibody targeting SCAP. Anti-SCAP Polyclonal Antibody can be used in ELISA,IF,IHC-Fr,IHC-P,WB.

IgG

(predicted:Human,Mouse,Rat,Chicken,Dog,Pig,Horse,Rabbit)

WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000

Polyclonal

KLH conjugated synthetic peptide: human SCAP

Human

SCAP

Sterol regulatory element-binding protein cleavage-activating protein

Cholesterol Metabolism,Cholesterol Metabolism,Lipid metabolism,Other Chaperones

Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.