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Jatrorrhizine hydroxide
🥰Excellent
Catalog No. T75436Cas No. 483-43-2
Jatrorrhizine hydroxide is an alkaloid extracted from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active acetylcholinesterase inhibitor (IC₅₀ = 872 nM) with over 115-fold selectivity over BuChE. Jatrorrhizine hydroxide reduces serotonin and norepinephrine uptake by blocking dopamine uptake-2 transporters.
Jatrorrhizine hydroxide
🥰Excellent
Purity: 99.99%
Catalog No. T75436Cas No. 483-43-2
Jatrorrhizine hydroxide is an alkaloid extracted from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active acetylcholinesterase inhibitor (IC₅₀ = 872 nM) with over 115-fold selectivity over BuChE. Jatrorrhizine hydroxide reduces serotonin and norepinephrine uptake by blocking dopamine uptake-2 transporters.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $31 | - | In Stock | |
| 10 mg | $51 | - | In Stock | |
| 25 mg | $92 | - | In Stock | |
| 50 mg | $157 | - | In Stock | |
| 100 mg | $237 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.99%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Jatrorrhizine hydroxide is an alkaloid extracted from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active acetylcholinesterase inhibitor (IC₅₀ = 872 nM) with over 115-fold selectivity over BuChE. Jatrorrhizine hydroxide reduces serotonin and norepinephrine uptake by blocking dopamine uptake-2 transporters. |
| Targets&IC50 | AChE:872 nM |
| In vitro | Jatrorrhizine hydroxide exhibits antimalarial and antiamebic activities, demonstrating inhibitory effects against both Plasmodium falciparum and E. histolytica, with IC50 values of 3.15 µM and 82.7 µM, respectively [1]. At concentrations of 25 μM and 50 μM, Jatrorrhizine hydroxide significantly inhibits the uptake of serotonin and norepinephrine in synaptosomes [3]. |
| In vivo | Jatrorrhizine hydroxide (5, 10, and 20 mg/kg, intraperitoneal injection) significantly reduced the immobility time of mice in the tail suspension test (TST) [2]. |
| Molecular Weight | 355.38 |
| Formula | C20H21NO5 |
| Cas No. | 483-43-2 |
| Smiles | [OH-].OC=1C=C2C(=CC1OC)C=3C=C4C=CC(OC)=C(OC)C4=C[N+]3CC2 |
| Color | Orange |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | H2O: 2 mg/mL (5.63 mM), Sonication is recommeded. DMSO: 2.5 mg/mL (7.03 mM), Sonication is recommeded. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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