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Ceforanide

Name: Ceforanide
Brand: TargetMol
SKU: T5022
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5022Cas No. 60925-61-3

Ceforanide is a second-generation cephalosporin antibiotic with bactericidal activity. Ceforanide causes inhibition of bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall.

Ceforanide

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Purity: 98.79%

Catalog No. T5022Cas No. 60925-61-3

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$67	In Stock	In Stock
50 mg	$115	In Stock	In Stock
100 mg	$167	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$38	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.79%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Ceforanide AI Summary

Ceforanide has a volume of distribution at steady state of 0.17 L.kg-1 and a clearance of 0.66 mL.min-1.kg-1 following intravenous administration, with a half-life of 3.0 hours and a mean residence time of 4.3 hours in humans. Its fraction unbound is 0.19 post-intravenous administration. The compound exhibits moderate liver toxicity observed in 42.9% of clinical trial subjects, including acute cytolytic and choleostatic liver toxicities, without severe hepatitis or liver tumors. Ceforanide has two acidic pKa values (2.01 and 3.63) and one basic pKa value (8.88), indicating interactions with both acidic and basic environments. The compound demonstrates antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration after 48 hours. However, the inhibition percentages suggest limited effectiveness (-9.18% and -0.17% respectively) and an IC50 of greater than 20,000 nM. It inhibits the SARS-CoV-2 3CL-Pro protease with -38.56% at 20 µM, indicating potential antiviral properties. Additionally, Ceforanide inhibits the human HDAC6 enzyme by -32.29% with a commercial peptide substrate. Notably, it shows low inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 and overall low bioactivity in various assays, with results greater than 30,000 nM indicating limited receptor or enzyme interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	519.55
Formula	C₂₀H₂₁N₇O₆S₂
Cas No.	60925-61-3
Smiles	[H][C@]12SCC(CSc3nnnn3CC(O)=O)=C(N1C(=O)[C@H]2NC(=O)Cc1ccccc1CN)C(O)=O
Relative Density.	1.79 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 59.375 mg/mL (114.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9247 mL	9.6237 mL	19.2474 mL	96.2371 mL
5 mM	0.3849 mL	1.9247 mL	3.8495 mL	19.2474 mL
10 mM	0.1925 mL	0.9624 mL	1.9247 mL	9.6237 mL
20 mM	0.0962 mL	0.4812 mL	0.9624 mL	4.8119 mL
50 mM	0.0385 mL	0.1925 mL	0.3849 mL	1.9247 mL
100 mM	0.0192 mL	0.0962 mL	0.1925 mL	0.9624 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc