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Anti-Phospho-p53 (Ser366) Polyclonal Antibody
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Catalog No. TMAC-02983
Alias p-p53 (Ser366), p-p53 (S366), p53 (p-Ser366), p53 (p-S366)
Anti-Phospho-p53 (Ser366) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser366). Anti-Phospho-p53 (Ser366) Polyclonal Antibody can be used in ELISA,IF,IHC,WB.
Anti-Phospho-p53 (Ser366) Polyclonal Antibody
Anti-Phospho-p53 (Ser366) Polyclonal Antibody
😃Good
Catalog No. TMAC-02983Alias p-p53 (Ser366), p-p53 (S366), p53 (p-Ser366), p53 (p-S366)
Anti-Phospho-p53 (Ser366) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser366). Anti-Phospho-p53 (Ser366) Polyclonal Antibody can be used in ELISA,IF,IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $216 | 7-10 days | 7-10 days | |
| 100 μL | $316 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-p53 (Ser366) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser366). Anti-Phospho-p53 (Ser366) Polyclonal Antibody can be used in ELISA,IF,IHC,WB. |
| Synonyms | p-p53 (Ser366), p-p53 (S366), p53 (p-Ser366), p53 (p-S366) |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of extracts from Rat heart using p53 (Phospho-Ser366) Antibody TMAC-02983. The lane on the left is treated with the antigen-specific peptide.  |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of Serine 366 (A-H-S(p)-S-H) derived from Human p53 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 48 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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