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KN-92 hydrochloride

Name: KN-92 hydrochloride
Brand: TargetMol
SKU: T8543
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8543Cas No. 1431698-47-3

KN-92 hydrochloride is an inactive derivative of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-93, which competitively blocks CaM binding to the kinase with a Ki of 370 nM.

KN-92 hydrochloride

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Purity: 99.68%

Catalog No. T8543Cas No. 1431698-47-3

KN-92 hydrochloride is an inactive derivative of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-93, which competitively blocks CaM binding to the kinase with a Ki of 370 nM.

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$106	In Stock
10 mg	$179	In Stock
25 mg	$297	In Stock
50 mg	$455	In Stock
100 mg	$645	In Stock
1 mL x 10 mM (in DMSO)	$115	In Stock

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Batch Information

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Purity:99.68%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description

KN-92 hydrochloride is an inactive derivative of the selective Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor KN-93, which competitively blocks CaM binding to the kinase with a Ki of 370 nM.

Chemical Properties

Molecular Weight	493.45
Formula	C₂₄H₂₆Cl₂N₂O₃S
Cas No.	1431698-47-3
Smiles	Cl.COc1ccc(cc1)S(=O)(=O)Nc1ccccc1CN(C)CC=Cc1ccc(Cl)cc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (81.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0265 mL	10.1327 mL	20.2655 mL	101.3274 mL
5 mM	0.4053 mL	2.0265 mL	4.0531 mL	20.2655 mL
10 mM	0.2027 mL	1.0133 mL	2.0265 mL	10.1327 mL
20 mM	0.1013 mL	0.5066 mL	1.0133 mL	5.0664 mL
50 mM	0.0405 mL	0.2027 mL	0.4053 mL	2.0265 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc