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Gypenoside XVII (Synonyms: Gynosaponin S, GP-17)

Name: Gypenoside XVII
Brand: TargetMol
SKU: T3385
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T3385 Copy Product Info

Purity: 99.89%

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Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathways.

Gypenoside XVII

Copy Product Info

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Catalog No. T3385

Synonyms Gynosaponin S, GP-17

Cas No. 80321-69-3

Pack Size	Price	USA Stock	Global Stock
1 mg	$41	In Stock	In Stock
5 mg	$92	In Stock	In Stock
10 mg	$145	In Stock	In Stock
25 mg	$261	In Stock	In Stock
50 mg	$387	In Stock	In Stock
100 mg	$575	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Gypenoside XVII AI Summary

Gypenoside XVII exhibits hepatoprotective activity against D-galactosamine/LPS-induced liver injury in mice by significantly inhibiting serum alanine transaminase (ALT) and aspartate transaminase (AST) levels, with inhibition rates of 95.0% for ALT and 91.0% for AST at a dosage of 100 mg/kg. This indicates its potential in protecting the liver from such damage. The compound shows no significant inhibition of human DNA topoisomerase 1 and 2, with IC50 values greater than 250,000.0 nM for both enzymes. Additionally, Gypenoside XVII functions as an inhibitor in various assays, including chronic active B-cell receptor signaling (16360.1 nM), ELG1-dependent DNA repair (29081.0 nM), HP1-beta chromodomain interactions with methylated histone tails (100000.0 nM), polymerase iota (89125.1 nM), and USP1/UAF1 (8912.5 nM). It also inhibits cell proliferation in human U251 cells (86.5% activity at 100 µM) and rat C6 cells (80.82% activity at 100 µM) after 72 hours. Furthermore, Gypenoside XVII exhibits inhibitory activity against human IDH1 R132H mutant and human IDH1, affecting the oxidation of NADPH to NADP+ and the reduction of NADP+ to NADPH, with activity levels of 101.9% and 122.0%, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathways.
Synonyms	Gynosaponin S, GP-17

Chemical Properties

Molecular Weight	947.15
Formula	C₄₈H₈₂O₁₈
Cas No.	80321-69-3
Smiles	[H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)C[C@]1([H])[C@@]3(C)CC[C@H](O[C@]4([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@]3([H])CC[C@@]21C)[C@](C)(CCC=C(C)C)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.38 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (63.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0558 mL	5.2790 mL	10.5580 mL	52.7899 mL
5 mM	0.2112 mL	1.0558 mL	2.1116 mL	10.5580 mL
10 mM	0.1056 mL	0.5279 mL	1.0558 mL	5.2790 mL
20 mM	0.0528 mL	0.2639 mL	0.5279 mL	2.6395 mL
50 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0558 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc