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2'-Deoxy-2'-fluorouridine

Name: 2'-Deoxy-2'-fluorouridine
Brand: TargetMol
SKU: T38239
Rating: 4.5 (1 reviews)

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Catalog No. T38239Cas No. 784-71-4

2'-Deoxy-2'-fluorouridine serves as an intermediate in the synthesis of antiviral agents targeting influenza viruses[1].

2'-Deoxy-2'-fluorouridine

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Purity: 99.93%

Catalog No. T38239Cas No. 784-71-4

2'-Deoxy-2'-fluorouridine serves as an intermediate in the synthesis of antiviral agents targeting influenza viruses[1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 g	$32	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

2'-Deoxy-2'-fluorouridine AI Summary

2'-Deoxy-2'-fluorouridine exhibits a broad spectrum of bioactivities including antiviral, antiherpetic, and antiproliferative properties across various cell types. It inhibits the influx competition with [6-3H]thymidine in mouse erythrocytes with a Ki of 120,000 nM. The compound demonstrates significant antiherpetic activity against HSV-1 (ED50 of 0.8 µM) and HSV-2 (ED50 of 6.0 µM), while inhibiting the growth of normal human lymphocytic cells with an ID50 greater than 100 µM. Additionally, 2'-Deoxy-2'-fluorouridine shows growth inhibition against a range of human tumor cell lines, including renal, breast, non-small cell lung, leukemia, ovarian, melanoma, central nervous system, prostate, and colon cells, with GI50 values spanning from nanomolar to micromolar concentrations, indicating its potency in cancer cell line inhibition. The compound also acts as an inhibitor of HCV 1b NS5b polymerase with an IC50 of 12,800 nM and demonstrates antiviral properties against RSV A2 by targeting RSV A2 RNA-dependent RNA polymerase in human Hep2 cells. Moreover, it shows inhibitory effects on human mitochondrial RNA polymerase and the mitochondrial DNA polymerase gamma complex..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

2'-Deoxy-2'-fluorouridine serves as an intermediate in the synthesis of antiviral agents targeting influenza viruses[1].

Chemical Properties

Molecular Weight	246.19
Formula	C₉H₁₁FN₂O₅
Cas No.	784-71-4
Smiles	OC[C@H]1O[C@H]([C@H](F)[C@@H]1O)n1ccc(=O)[nH]c1=O
Relative Density.	1.63 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (406.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (16.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0619 mL	20.3095 mL	40.6190 mL	203.0952 mL
5 mM	0.8124 mL	4.0619 mL	8.1238 mL	40.6190 mL
10 mM	0.4062 mL	2.0310 mL	4.0619 mL	20.3095 mL
20 mM	0.2031 mL	1.0155 mL	2.0310 mL	10.1548 mL
50 mM	0.0812 mL	0.4062 mL	0.8124 mL	4.0619 mL
100 mM	0.0406 mL	0.2031 mL	0.4062 mL	2.0310 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc