Shopping Cart

Your shopping cart is currently empty

Clofarabine

Name: Clofarabine
Brand: TargetMol
SKU: T0297
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T0297Cas No. 123318-82-1

Alias Evoltra, Clolar, Clofarex

Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

Clofarabine

🥰Excellent

Purity: 99.94%

Catalog No. T0297Alias Evoltra, Clolar, ClofarexCas No. 123318-82-1

Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$36	In Stock	In Stock
10 mg	$54	In Stock	In Stock
25 mg	$87	In Stock	In Stock
50 mg	$135	In Stock	In Stock
100 mg	$175	In Stock	In Stock
200 mg	$227	In Stock	In Stock
500 mg	$379	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.94%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
Targets&IC50	Ribonucleotide reductase:65 nM
In vitro	In athymic nude mice or severe combined immunodeficient (SCID) mice, Clofarabine demonstrates inhibitory effects on various subcutaneously transplanted human tumor xenografts.
In vivo	In lymphocytes from chronic lymphocytic leukemia, 10 μM Clofarabine inhibits the repair induced by 4-hydroperoxycyclophosphamide with a peak inhibition at an intracellular concentration of 5 μM. Across a range of leukemia and solid tumor cell lines, Clofarabine demonstrates potent growth inhibition and cytotoxicity (IC50= 0.028–0.29 μM).
Synonyms	Evoltra, Clolar, Clofarex

Chemical Properties

Molecular Weight	303.68
Formula	C₁₀H₁₁ClFN₅O₃
Cas No.	123318-82-1
Smiles	Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F
Relative Density.	2.12 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (131.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2929 mL	16.4647 mL	32.9294 mL	164.6470 mL
5 mM	0.6586 mL	3.2929 mL	6.5859 mL	32.9294 mL
10 mM	0.3293 mL	1.6465 mL	3.2929 mL	16.4647 mL
20 mM	0.1646 mL	0.8232 mL	1.6465 mL	8.2323 mL
50 mM	0.0659 mL	0.3293 mL	0.6586 mL	3.2929 mL
100 mM	0.0329 mL	0.1646 mL	0.3293 mL	1.6465 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc