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4-Hydroxychalcone

Name: 4-Hydroxychalcone
Brand: TargetMol
SKU: T3005
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3005Cas No. 20426-12-4

Alias P-Cinnamoylphenol

4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.

4-Hydroxychalcone

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Purity: 99.75%

Catalog No. T3005Alias P-CinnamoylphenolCas No. 20426-12-4

4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$40	In Stock	In Stock
500 mg	$88	In Stock	In Stock
1 g	$128	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:White

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COA HPLC HNMR LCMS

Product Introduction

4-Hydroxychalcone AI Summary

4-Hydroxychalcone exhibits a diverse range of bioactivities across various biological pathways and targets. It demonstrates inhibitory effects on cell proliferation in murine P388, L1210 leukemia, human Molt 4/C8 T-lymphocyte, and Human CEM T-lymphocytes cells with IC50 values ranging from 8580.0 nM to 37900.0 nM. It induces NAD(P)H quinone reductase activity in Hepa 1c1c7 murine hepatoma cells with a CD of 33.0 µM, suggesting antioxidant or detoxifying properties. The compound also inhibits the recombinant rat androgen receptor with an IC50 of 47863.01 nM, blocks the human K+ channel in HEK293 cells with an IC50 > 50000.0 nM, and inhibits cobalt chloride-induced HIF-1 activation in mouse NIH3T3 cells with an IC50 > 20000.0 nM. 4-Hydroxychalcone exhibits antifungal activity against Candida albicans with a MIC of 62.5 µg/mL and a zone of inhibition diameter of 15.0 mm, and exhibits antifungal effects on Saccharomyces cerevisiae, Hansenula polymorpha, and Kluyveromyces lactis with MIC values > 40.0 µg/mL. It shows antibacterial activity against Staphylococcus aureus Rosenbach 209 and multidrug-resistant bacterial strains, with MIC values ranging from 32.0 µg/mL to 1000.0 µg/mL, demonstrating synergism with ciprofloxacin and doxycycline. The compound also exhibits cytotoxicity against Homo sapiens HT-29 and SGC7901 cells with IC50 values of 24600.0 nM and 13740.0 nM, respectively, and against mouse NIH/3T3 cells with less than 5.0% activity after 8 hours. 4-Hydroxychalcone shows anti-inflammatory activity by inhibiting carrageenan-induced paw edema in rats at 25 mg/kg with an inhibition of 0.165%. It inhibits TNFalpha-induced NF-kappaB activation in human A549 and K562 cells with IC50 values > 20000.0 nM and 24000.0 nM, respectively. The compound demonstrates anti-leishmanial activity against Leishmania major with an IC50 of 4000.0 nM and antioxidant activity, including DPPH radical scavenging and inhibition of bovine xanthine oxidase with IC50 values of 290000.0 nM. 4-Hydroxychalcone exhibits enzyme inhibition, notably affecting rhodanese, MDH, GroEL/GroES-mediated protein refolding, ATPase activity, and chaperone proteins such as Escherichia coli GroEL/GroES and human mitochondrial HSP60/HSP10. It inhibits PMA-induced ROS/RNS generation in human neutrophils with IC50 values of 8800.0 nM and 11600.0 nM at different glucose concentrations. Lastly, the compound also shows antidiabetic activity by decreasing glucose consumption in 3T3L1 cells, suggesting potential multifaceted therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
Synonyms	P-Cinnamoylphenol

Chemical Properties

Molecular Weight	224.25
Formula	C₁₅H₁₂O₂
Cas No.	20426-12-4
Smiles	OC1=CC=C(\C=C\C(=O)C2=CC=CC=C2)C=C1
Relative Density.	1.191 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1114.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4593 mL	22.2965 mL	44.5931 mL	222.9654 mL
5 mM	0.8919 mL	4.4593 mL	8.9186 mL	44.5931 mL
10 mM	0.4459 mL	2.2297 mL	4.4593 mL	22.2965 mL
20 mM	0.2230 mL	1.1148 mL	2.2297 mL	11.1483 mL
50 mM	0.0892 mL	0.4459 mL	0.8919 mL	4.4593 mL
100 mM	0.0446 mL	0.2230 mL	0.4459 mL	2.2297 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc