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Anti-HMGN2/HMG17 Polyclonal Antibody
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Catalog No. TMAB-07190
Anti-HMGN2/HMG17 Polyclonal Antibody is a Rabbit antibody targeting HMGN2/HMG17. Anti-HMGN2/HMG17 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-HMGN2/HMG17 Polyclonal Antibody
Anti-HMGN2/HMG17 Polyclonal Antibody
😃Good
Catalog No. TMAB-07190
Anti-HMGN2/HMG17 Polyclonal Antibody is a Rabbit antibody targeting HMGN2/HMG17. Anti-HMGN2/HMG17 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-HMGN2/HMG17 Polyclonal Antibody is a Rabbit antibody targeting HMGN2/HMG17. Anti-HMGN2/HMG17 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human,Dog,Pig,Cow,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription (1–5). HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates (1–3,5). HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence (1–3). Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber (1–3). In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development (2). |
| Immunogen | KLH conjugated synthetic peptide: human HMGN2/HMG17 |
| Antigen Species | Human |
| Gene Name | HMGN2 |
| Gene ID | |
| Protein Name | Non-histone chromosomal protein HMG-17 |
| Uniprot ID | |
| Function | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. |
| Molecular Weight | Theoretical: 9.2 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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