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Cloxiquine

Name: Cloxiquine
Brand: TargetMol
SKU: T0509
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0509Cas No. 130-16-5

Alias Dermofungin, Dermofongin, 5-Chloro-8-quinolinol

Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.

Cloxiquine

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Purity: 99.87%

Catalog No. T0509Alias Dermofungin, Dermofongin, 5-Chloro-8-quinolinolCas No. 130-16-5

Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$31	-	In Stock
10 g	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Cloxiquine AI Summary

Cloxiquine demonstrates notable bioactivity across a broad spectrum of targets, exhibiting potent antimycobacterial efficacy against multiple Mycobacterium tuberculosis strains, including drug-resistant varieties with a low MIC of 0.125 ug/mL. It is effective against pulmonary tuberculosis isolates, with MIC50 and MIC90 values of 0.125 ug/mL and 0.25 ug/mL, respectively. The compound displays moderating influence on Lamin A splicing, inhibition of Tau fibril formation, and various enzyme activities including significant inhibition of MMP enzymes and human integrase. At a concentration of 1 mM, it inhibits MMP2 (60.0%), MMP8 (73.0%), MMP1 (39.0%), and MMP3 (45.0%), but shows minimal inhibition of MMP9. Additionally, it doesn't affect mushroom tyrosinase. It exhibits moderate lipophilicity with a logP around 2.91-2.94, and pKa values indicating potential ionization variability in different environments, potentially impacting its solubility and bioavailability. Further, Cloxiquine inhibits human methionine aminopeptidase 2 with an IC50 of 1270.0 nM and 1A from Rickettsia prowazekii with IC50 of 900.0 nM. It also inhibits the protease activity of Clostridium botulinum with an IC50 of 1900.0 nM and displays significant inhibitory actions against the NDM-1 enzyme. Its activities extend to inhibition of BRD4 and COMT in rat liver, alongside moderate cytotoxicity against human cancer cell lines MES-SA and MES-SA/Dx5 with IC50 values between 5130.0 to 8320.0 nM. Cloxiquine also shows antiviral properties, particularly against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and VERO-6 cells, although with a relatively high IC50 value (> 20,000.0 nM). Moreover, it reveals inhibition of human HDAC6 and BSEP activities, signifying its broad-spectrum potential in various biological assays and therapeutic possibilities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cloxiquine (Dermofongin) is a monohalogenated 8-hydroxyquinoline with activity against bacteria, fungi, and protozoa.
Synonyms	Dermofungin, Dermofongin, 5-Chloro-8-quinolinol

Chemical Properties

Molecular Weight	179.6
Formula	C₉H₆ClNO
Cas No.	130-16-5
Smiles	ClC=1C2=C(C(O)=CC1)N=CC=C2
Relative Density.	1.412 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (306.24 mM), Sonication is recommended.

Ethanol: 33 mg/mL (183.74 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5679 mL	27.8396 mL	55.6793 mL	278.3964 mL
5 mM	1.1136 mL	5.5679 mL	11.1359 mL	55.6793 mL
10 mM	0.5568 mL	2.7840 mL	5.5679 mL	27.8396 mL
20 mM	0.2784 mL	1.3920 mL	2.7840 mL	13.9198 mL
50 mM	0.1114 mL	0.5568 mL	1.1136 mL	5.5679 mL
100 mM	0.0557 mL	0.2784 mL	0.5568 mL	2.7840 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc