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Cyclo-(Pro-Gly)

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Catalog No. TN6674Cas No. 19179-12-5
Alias Pyrrolopiperazine-2,5-dione, Cyclo(Pro-Gly)

Cyclo-(Pro-Gly) is an alkaloid with weak antibacterial activity and antioxidant properties that can inhibit Chitinase B and scavenge free radicals. It is widely used in biochemical experiments and drug synthesis research.

Cyclo-(Pro-Gly)

Cyclo-(Pro-Gly)

🥰Excellent
Purity: 99.33%
Catalog No. TN6674Alias Pyrrolopiperazine-2,5-dione, Cyclo(Pro-Gly)Cas No. 19179-12-5
Cyclo-(Pro-Gly) is an alkaloid with weak antibacterial activity and antioxidant properties that can inhibit Chitinase B and scavenge free radicals. It is widely used in biochemical experiments and drug synthesis research.
Pack SizePriceAvailabilityQuantity
25 mg$29In Stock
1 mL x 10 mM (in DMSO)$32In Stock
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Purity:99.33%
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Product Introduction

Bioactivity
Description
Cyclo-(Pro-Gly) is an alkaloid with weak antibacterial activity and antioxidant properties that can inhibit Chitinase B and scavenge free radicals. It is widely used in biochemical experiments and drug synthesis research.
In vitro
METHODS AND RESULTS:In the present study, an endophytic fungus isolate FTJZZJ09, which isolated from the fresh bulbs of Fritillaria thunbergii Miq., was identified as Penicillium chrysogenum based on its morphological characters and internal transcribed spacer (ITS) sequence. After being cultured in the modified CzapeK-DoX medium (3 g/L maltose, 3 g/L peptone A, 0.1 g/L K2HPO4, 0.05 g/L KCl, 0.3 g/L NaNO3, 0.05 g/L MgSO4·7H2O, 0.001 g/L FeSO4·7H2O, pH 6.5), it can secrete antibacterial metabolites under the condition of 28 °C in a rotary shaker at 160 r/min for 7 days. Three antibacterial compounds were isolated from the ethyl acetate extract of the fermentation broth by silica gel, they were elucidated as Cyclo(Pro-Gly) , cyclo (Pro-Val) and 2-acetyl-4 (3H) quinazolinone. CONCLUSIONS: All the three compounds could inhibit the growth of Bacillus subtilis with the minimal inhibitory concentration (MIC) value of 0.8, 0.8, and 0.4 g/L respectively, while they showed no apparent effects against the growth of Gram-negative bacteria.
In vivo
Cyclo-(Pro-Gly) (0.1, 10 mg/kg, intraperitoneal injection) administered to rats appears to be a memory-enhancing substance in rats, suggesting the existence of a new memory regulation mechanism in rats. [1]
AliasPyrrolopiperazine-2,5-dione, Cyclo(Pro-Gly)
Chemical Properties
Molecular Weight154.17
FormulaC7H10N2O2
Cas No.19179-12-5
SmilesO=C1NCC(=O)N2CCCC12
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (518.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM6.4863 mL32.4317 mL64.8635 mL324.3173 mL
5 mM1.2973 mL6.4863 mL12.9727 mL64.8635 mL
10 mM0.6486 mL3.2432 mL6.4863 mL32.4317 mL
20 mM0.3243 mL1.6216 mL3.2432 mL16.2159 mL
50 mM0.1297 mL0.6486 mL1.2973 mL6.4863 mL
100 mM0.0649 mL0.3243 mL0.6486 mL3.2432 mL

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