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Cyclo-(Pro-Gly)

Name: Cyclo-(Pro-Gly)
Brand: TargetMol
SKU: TN6674
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6674Cas No. 19179-12-5

Alias Pyrrolopiperazine-2,5-dione, Cyclo(Pro-Gly)

Cyclo-(Pro-Gly) is an alkaloid with weak antibacterial activity and antioxidant properties that can inhibit Chitinase B and scavenge free radicals. It is widely used in biochemical experiments and drug synthesis research.

Cyclo-(Pro-Gly)

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Purity: 99.33%

Catalog No. TN6674Alias Pyrrolopiperazine-2,5-dione, Cyclo(Pro-Gly)Cas No. 19179-12-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$32	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.33%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Cyclo-(Pro-Gly) is an alkaloid with weak antibacterial activity and antioxidant properties that can inhibit Chitinase B and scavenge free radicals. It is widely used in biochemical experiments and drug synthesis research.
In vitro	METHODS AND RESULTS:In the present study, an endophytic fungus isolate FTJZZJ09, which isolated from the fresh bulbs of Fritillaria thunbergii Miq., was identified as Penicillium chrysogenum based on its morphological characters and internal transcribed spacer (ITS) sequence. After being cultured in the modified CzapeK-DoX medium (3 g/L maltose, 3 g/L peptone A, 0.1 g/L K2HPO4, 0.05 g/L KCl, 0.3 g/L NaNO3, 0.05 g/L MgSO4·7H2O, 0.001 g/L FeSO4·7H2O, pH 6.5), it can secrete antibacterial metabolites under the condition of 28 °C in a rotary shaker at 160 r/min for 7 days. Three antibacterial compounds were isolated from the ethyl acetate extract of the fermentation broth by silica gel, they were elucidated as Cyclo(Pro-Gly) , cyclo (Pro-Val) and 2-acetyl-4 (3H) quinazolinone. CONCLUSIONS: All the three compounds could inhibit the growth of Bacillus subtilis with the minimal inhibitory concentration (MIC) value of 0.8, 0.8, and 0.4 g/L respectively, while they showed no apparent effects against the growth of Gram-negative bacteria.
In vivo	Cyclo-(Pro-Gly) (0.1, 10 mg/kg, intraperitoneal injection) administered to rats appears to be a memory-enhancing substance in rats, suggesting the existence of a new memory regulation mechanism in rats. [1]
Synonyms	Pyrrolopiperazine-2,5-dione, Cyclo(Pro-Gly)

Chemical Properties

Molecular Weight	154.17
Formula	C₇H₁₀N₂O₂
Cas No.	19179-12-5
Smiles	O=C1NCC(=O)N2CCCC12
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (518.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (32.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4863 mL	32.4317 mL	64.8635 mL	324.3173 mL
5 mM	1.2973 mL	6.4863 mL	12.9727 mL	64.8635 mL
10 mM	0.6486 mL	3.2432 mL	6.4863 mL	32.4317 mL
20 mM	0.3243 mL	1.6216 mL	3.2432 mL	16.2159 mL
50 mM	0.1297 mL	0.6486 mL	1.2973 mL	6.4863 mL
100 mM	0.0649 mL	0.3243 mL	0.6486 mL	3.2432 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc