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Anti-HTR2C Antibody (4V21) (Synonyms: Serotonin receptor 2C, HTR1C, 5-hydroxytryptamine receptor 2C, 5-hydrox...)

Catalog No. TMAH-00583 Copy Product Info
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Anti-HTR2C Antibody (4V21) is an antibody targeting HTR2C. Anti-HTR2C Antibody (4V21) can be used in ELISA,IHC,WB.

Anti-HTR2C Antibody (4V21)

Copy Product Info
🥰Excellent
Catalog No. TMAH-00583
Synonyms Serotonin receptor 2C, HTR1C, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1C, 5-HTR2C, 5-HT-2C, 5-HT2C, 5-HT-1C, 5-HT1C

Anti-HTR2C Antibody (4V21) is an antibody targeting HTR2C. Anti-HTR2C Antibody (4V21) can be used in ELISA,IHC,WB.

Anti-HTR2C Antibody
(4V21)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2097-10 days7-10 days
100 μL$3477-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-HTR2C Antibody (4V21) is an antibody targeting HTR2C. Anti-HTR2C Antibody (4V21) can be used in ELISA,IHC,WB.
SynonymsSerotonin receptor 2C, HTR1C, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1C, 5-HTR2C, 5-HT-2C, 5-HT2C, 5-HT-1C, 5-HT1C
Ig Type
Rabbit IgG
Clone
4V21
Reactivity
Human
Verified Activity
1. Western Blot
-Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
-All lanes: HTR2C antibody at 1:2000
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 52, 29 kDa
-Observed band size: 75 kDa
2. IHC image of TMAH-00583 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Application
Recommended Dose
WB:1:500-1:5000; IHC:1:50-1:200.
Antibody Type
Monoclonal
Subcellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue SpecificityDetected in brain.
ConstructionRecombinant Antibody
PurificationAffinity-chromatography
AppearanceLiquid
FormulationPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundG-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
A synthetic peptide: Human 5HT2C Receptor
Antigen Species
Human
Gene Name
HTR2C
Gene ID
Uniprot ID
Biology Area
Neuroscience, Metabolism, Signal transduction
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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