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Anti-HTR2C Antibody (4V21)
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Catalog No. TMAH-00583
Alias Serotonin receptor 2C, HTR1C, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1C, 5-HTR2C, 5-HT-2C, 5-HT2C, 5-HT-1C, 5-HT1C
Anti-HTR2C Antibody (4V21) is an antibody targeting HTR2C. Anti-HTR2C Antibody (4V21) can be used in ELISA, WB, IHC.
Anti-HTR2C Antibody (4V21)
Anti-HTR2C Antibody (4V21)
😃Good
Catalog No. TMAH-00583Alias Serotonin receptor 2C, HTR1C, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1C, 5-HTR2C, 5-HT-2C, 5-HT2C, 5-HT-1C, 5-HT1C
Anti-HTR2C Antibody (4V21) is an antibody targeting HTR2C. Anti-HTR2C Antibody (4V21) can be used in ELISA, WB, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $209 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-HTR2C Antibody (4V21) is an antibody targeting HTR2C. Anti-HTR2C Antibody (4V21) can be used in ELISA, WB, IHC. |
| Alias | Serotonin receptor 2C, HTR1C, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1C, 5-HTR2C, 5-HT-2C, 5-HT2C, 5-HT-1C, 5-HT1C |
| Ig Type | Rabbit IgG |
| Clone | 4V21 |
| Reactivity | Human |
| Verified Activity | 1. Western Blot -Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate -All lanes: HTR2C antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 52, 29 kDa -Observed band size: 75 kDa 2. IHC image of TMAH-00583 diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| Application | ELISA, WB, IHC |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human 5HT2C Receptor |
| Antigen Species | Human |
| Gene ID | 3358 |
| Uniprot ID | |
| Biology Area | Neuroscience, Metabolism, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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