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Ginsenoside Rd
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Catalog No. T2878Cas No. 52705-93-8
Alias Sanchinoside Rd, Panaxoside Rd, Gypenoside VIII
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
Ginsenoside Rd
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Purity: 99.92%
Catalog No. T2878Alias Sanchinoside Rd, Panaxoside Rd, Gypenoside VIIICas No. 52705-93-8
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $33 | In Stock | In Stock | |
| 5 mg | $68 | In Stock | In Stock | |
| 10 mg | $106 | In Stock | In Stock | |
| 25 mg | $189 | In Stock | In Stock | |
| 50 mg | $289 | In Stock | In Stock | |
| 100 mg | $438 | - | In Stock | |
| 200 mg | $633 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $133 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.92%
Color:White
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Product Introduction
Ginsenoside Rd AI Summary
Ginsenoside Rd shows hepatoprotective activity in mouse hepatocytes, effectively inhibiting D-galactosamine/TNFalpha-induced cell death at concentrations of 50 uM, 100 uM, and 200 uM, with inhibition percentages ranging from 17.5% to 39.1%. It also provides protective activity against the same stimuli, with percentages between 7.4% and 16.8%. Furthermore, it demonstrates significant hepatoprotective effects in ddY mice against D-galactosamine/LPS-induced liver injury, reducing serum alanine transaminase and aspartate transaminase levels by 97.0% and 93.0%, respectively, at a dose of 100 mg/kg.
In addition, Ginsenoside Rd does not significantly inhibit human DNA topoisomerase 1 or 2, showing IC50 values greater than 250,000 nM. It inhibits superoxide anion generation in human neutrophils stimulated by fMLP/CB slightly at 30 uM, as evidenced by a -3.54% inhibition. It also modestly inhibits human neutrophil degranulation with a 2.88% inhibition of elastase release at the same concentration.
The compound inhibits cell proliferation in human U251 cells and rat C6 cells, with inhibition rates of 78.36% and 102.07%, respectively, after 72 hours, as measured by the sulforhodamine B assay. Additionally, it activates AMPKalpha2beta1gamma1 in the presence of CaMKKbeta with an EC50 value of 16.8 nM.
Antiviral properties of Ginsenoside Rd include the inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 uM, with inhibition rates of -4.52% and -0.06%, respectively, after 48 hours. Moreover, it inhibits SARS-CoV-2 3CL-Pro protease by 7.699% at 20 µM. Lastly, the compound exhibits weak HDAC6 inhibitory activity, with inhibition percentages of 6.33% using commercial substrates and 0.27% with custom peptide substrates..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors. |
| Targets&IC50 | CYP3A4:81.7±2.6 μM, NF-κB:12.05 μM (in HepG2 cells), CYP1A2:78.4±5.3 μM, CYP2D6:58.0±4.5 μM, CYP2C9:85.1±9.1 μM |
| Synonyms | Sanchinoside Rd, Panaxoside Rd, Gypenoside VIII |
| Molecular Weight | 947.15 |
| Formula | C48H82O18 |
| Cas No. | 52705-93-8 |
| Smiles | [H][C@@]12[C@H](CC[C@@]1(C)[C@]1(C)CC[C@@]3([H])C(C)(C)[C@H](CC[C@]3(C)[C@@]1([H])C[C@H]2O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(C)(CCC=C(C)C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |
| Relative Density. | 1.37 g/cm3 |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (52.79 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.11 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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