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MMAF-OMe

Name: MMAF-OMe
Brand: TargetMol
SKU: T12081
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12081Cas No. 863971-12-4

Alias Monomethyl auristatin F methyl ester

MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin.

MMAF-OMe

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Purity: 99.34%

Catalog No. T12081Alias Monomethyl auristatin F methyl esterCas No. 863971-12-4

Pack Size	Price	Availability
5 mg	$34	In Stock
10 mg	$52	In Stock
25 mg	$82	In Stock

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Purity:99.34%

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COA HNMR HPLC

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin.
In vitro	2.5F-Fc and 2.5F-Fc-MMAF exhibit similar IC50 values (6.9±1.1 vs. 8.3±1.3 nM, respectively)[1], indicating that MMAF conjugation has a negligible impact on integrin-binding affinity[1].
Alias	Monomethyl auristatin F methyl ester

Chemical Properties

Molecular Weight	745.99
Formula	C₄₀H₆₇N₅O₈
Cas No.	863971-12-4
Smiles	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC)OC)N(C)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)C
Relative Density.	1.095 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 99 mg/mL (132.71 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+95% Saline: 4 mg/mL (5.36 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3405 mL	6.7025 mL	13.4050 mL	67.0250 mL
5 mM	0.2681 mL	1.3405 mL	2.6810 mL	13.4050 mL
10 mM	0.1341 mL	0.6703 mL	1.3405 mL	6.7025 mL
20 mM	0.0670 mL	0.3351 mL	0.6703 mL	3.3513 mL
50 mM	0.0268 mL	0.1341 mL	0.2681 mL	1.3405 mL
100 mM	0.0134 mL	0.0670 mL	0.1341 mL	0.6703 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc