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Anti-ORP4/OSBP2 Polyclonal Antibody
😃Good
Catalog No. TMAB-09803
Anti-ORP4/OSBP2 Polyclonal Antibody is a Rabbit antibody targeting ORP4/OSBP2. Anti-ORP4/OSBP2 Polyclonal Antibody can be used in WB.
Anti-ORP4/OSBP2 Polyclonal Antibody
Anti-ORP4/OSBP2 Polyclonal Antibody
😃Good
Catalog No. TMAB-09803
Anti-ORP4/OSBP2 Polyclonal Antibody is a Rabbit antibody targeting ORP4/OSBP2. Anti-ORP4/OSBP2 Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ORP4/OSBP2 Polyclonal Antibody is a Rabbit antibody targeting ORP4/OSBP2. Anti-ORP4/OSBP2 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Peripheral membrane protein |
| Tissue Specificity | Expressed mainly in retina, testis, and fetal liver. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells. |
| Immunogen | KLH conjugated synthetic peptide: human ORP4/OSBP2 |
| Antigen Species | Human |
| Gene Name | OSBP2 |
| Gene ID | |
| Protein Name | Oxysterol-binding protein 2 |
| Uniprot ID | |
| Function | Binds 7-ketocholesterol. |
| Molecular Weight | Theoretical: 101 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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