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NPD8733
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Catalog No. T9008Cas No. 696655-62-6
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration, specifically binding to valosin-containing protein (VCP)/p97.
NPD8733
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Purity: 98.48%
Catalog No. T9008Cas No. 696655-62-6
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration, specifically binding to valosin-containing protein (VCP)/p97.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $47 | In Stock | In Stock | |
| 10 mg | $76 | In Stock | In Stock | |
| 25 mg | $155 | In Stock | In Stock | |
| 50 mg | $251 | In Stock | In Stock | |
| 100 mg | $407 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $54 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.48%
Appearance:Solid
Color:White
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Product Introduction
NPD8733 AI Summary
NPD8733 exhibits diverse bioactivities targeting multiple biological pathways and mechanisms. It shows inhibitory potency against Influenza NS1 Protein Function at 12589.3 nM, and against ELG1-dependent DNA repair in HEK293T cells with a potency of 103.2 nM. The compound impacts delayed death in the malarial parasite plastid, with potencies of 11689.1 nM over 96 hours and 2616.9 nM over 48 hours. It also inhibits interactions of HP1-beta Chromodomain with Methylated Histone Tails at 14125.4 nM. Additionally, it inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 20596.2 nM in the absence of CPT and 6513.1 nM in its presence. The compound has shown inhibitory activity against AMA1-RON for developing antimalarial drugs with a potency of 7943.3 nM. However, it has relatively low inhibitory activity against GST-fused VCP, with an IC50 greater than 100,000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration, specifically binding to valosin-containing protein (VCP)/p97. |
| Molecular Weight | 309.32 |
| Formula | C18H15NO4 |
| Cas No. | 696655-62-6 |
| Smiles | COc1ccc(cc1)C(=O)c1oc2ccccc2c1NC(C)=O |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (35.56 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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