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Harmol

Name: Harmol
Brand: TargetMol
SKU: T3152
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3152Cas No. 487-03-6

Alias Methylpyridoindolol

Harmol, a β-carboline alkaloid, is a monoamine oxidase inhibitor that can be used as an analytical reference standard.

Harmol

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Purity: 99.90%

Catalog No. T3152Alias MethylpyridoindololCas No. 487-03-6

Harmol, a β-carboline alkaloid, is a monoamine oxidase inhibitor that can be used as an analytical reference standard.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$108	In Stock	In Stock
50 mg	$163	In Stock	In Stock
100 mg	$243	In Stock	In Stock
200 mg	$362	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.90%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Harmol AI Summary

Harmol exhibits multifaceted bioactivity, serving as an inhibitor of human recombinant full-length GST-tagged DYRK1A with an IC50 value of 90.0 nM, which reduces tau phosphorylation at S396. It demonstrates antibacterial activity against Klebsiella pneumoniae and Staphylococcus aureus with moderate inhibitory effects (7.41% to 20.45%), and weaker activity against Pseudomonas aeruginosa, Acinetobacter baumannii, and Candida albicans (inhibition range -8.88% to 15.56%). It shows no significant antifungal activity against Cryptococcus neoformans but exhibits notable antifungal activity against Alternaria solani (26.3%) and Bipolaris maydis (31.8%). Additionally, Harmol acts as an antiviral against SARS-CoV-2, inferring inhibition of cytotoxicity in VERO-6 cells at 10 µM with an IC50 value greater than 19952.62 nM. Furthermore, it inhibits HASPIN enzyme with an IC50 value of 770.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Harmol, a β-carboline alkaloid, is a monoamine oxidase inhibitor that can be used as an analytical reference standard.
Synonyms	Methylpyridoindolol

Chemical Properties

Molecular Weight	198.22
Formula	C₁₂H₁₀N₂O
Cas No.	487-03-6
Smiles	Cc1nccc2c3ccc(O)cc3[nH]c12
Relative Density.	1.33g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1261.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0449 mL	25.2245 mL	50.4490 mL	252.2450 mL
5 mM	1.0090 mL	5.0449 mL	10.0898 mL	50.4490 mL
10 mM	0.5045 mL	2.5224 mL	5.0449 mL	25.2245 mL
20 mM	0.2522 mL	1.2612 mL	2.5224 mL	12.6122 mL
50 mM	0.1009 mL	0.5045 mL	1.0090 mL	5.0449 mL
100 mM	0.0504 mL	0.2522 mL	0.5045 mL	2.5224 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc