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Anti-CDKN2B/p15 INK4b Polyclonal Antibody
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Catalog No. TMAB-04185
Anti-CDKN2B/p15 INK4b Polyclonal Antibody is a Rabbit antibody targeting CDKN2B/p15 INK4b. Anti-CDKN2B/p15 INK4b Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-CDKN2B/p15 INK4b Polyclonal Antibody
Anti-CDKN2B/p15 INK4b Polyclonal Antibody
😃Good
Catalog No. TMAB-04185
Anti-CDKN2B/p15 INK4b Polyclonal Antibody is a Rabbit antibody targeting CDKN2B/p15 INK4b. Anti-CDKN2B/p15 INK4b Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CDKN2B/p15 INK4b Polyclonal Antibody is a Rabbit antibody targeting CDKN2B/p15 INK4b. Anti-CDKN2B/p15 INK4b Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Chicken,Dog,Cow,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Note=Also found in the nucleus. |
| Tissue Specificity | Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | p15 INK4b / MTS 2 (Mitotic Inhibitor / Suppressor Protein) is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during the cell cycle. Reportedly, p15 INK4b expression is induced approximately 30 fold in human keratinocytes by treatment with TGF beta, suggesting that p15 INK4b may act as an effector of TGF beta mediated cell cycle arrest. p15 INK4b is mapped to chromosome 9p21, a region of frequent loss in a wide variety of cancers. |
| Immunogen | KLH conjugated synthetic peptide: human CDKN2B |
| Antigen Species | Human |
| Gene Name | CDKN2B |
| Gene ID | |
| Protein Name | Cyclin-dependent kinase 4 inhibitor B |
| Uniprot ID | |
| Function | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. |
| Molecular Weight | Theoretical: 15 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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