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Anti-CDKN2B/p15 INK4b Polyclonal Antibody
Catalog No. TMAB-04185 Copy Product Info
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Anti-CDKN2B/p15 INK4b Polyclonal Antibody is a Rabbit antibody targeting CDKN2B/p15 INK4b. Anti-CDKN2B/p15 INK4b Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-CDKN2B/p15 INK4b Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-04185
Anti-CDKN2B/p15 INK4b Polyclonal Antibody is a Rabbit antibody targeting CDKN2B/p15 INK4b. Anti-CDKN2B/p15 INK4b Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-CDKN2B/p15 INK4b Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-CDKN2B/p15 INK4b Polyclonal Antibody is a Rabbit antibody targeting CDKN2B/p15 INK4b. Anti-CDKN2B/p15 INK4b Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Chicken,Dog,Cow,Rabbit) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (Rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (CDKN2B) Polyclonal Antibody, Unconjugated (TMAB-04185) at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Note=Also found in the nucleus. |
| Tissue Specificity | Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | p15 INK4b / MTS 2 (Mitotic Inhibitor / Suppressor Protein) is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during the cell cycle. Reportedly, p15 INK4b expression is induced approximately 30 fold in human keratinocytes by treatment with TGF beta, suggesting that p15 INK4b may act as an effector of TGF beta mediated cell cycle arrest. p15 INK4b is mapped to chromosome 9p21, a region of frequent loss in a wide variety of cancers. |
| Immunogen | KLH conjugated synthetic peptide: human CDKN2B |
| Antigen Species | Human |
| Gene Name | CDKN2B |
| Gene ID | |
| Protein Name | Cyclin-dependent kinase 4 inhibitor B |
| Uniprot ID | |
| Function | Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. |
| Molecular Weight | Theoretical: 15 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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