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UNC3866

Name: UNC3866
Brand: TargetMol
SKU: T4021
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4021Cas No. 1872382-47-2

UNC3866 is a potent antagonist of the CBX7-H3 interaction, as determined by AlphaScreen.

UNC3866

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Purity: 99.62%

Catalog No. T4021Cas No. 1872382-47-2

UNC3866 is a potent antagonist of the CBX7-H3 interaction, as determined by AlphaScreen.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$117	In Stock	In Stock
10 mg	$189	In Stock	In Stock
25 mg	$338	In Stock	In Stock
50 mg	$497	In Stock	In Stock
100 mg	$762	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$162	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.62%

Color:White

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COA LCMS MS

Product Introduction

UNC3866 AI Summary

UNC3866 exhibits binding affinity to various chromodomains, including CBX4, CBX7, CBX2, CBX6, CBX8, CDY1, CDYL1b, and CDYL2. It demonstrates selectivity towards certain chromodomains with observable selectivity ratios. The compound acts as an antagonist against CBX4, CBX7, CBX8, and CDYL2, as evidenced by IC50 values. Specific dissociation constants (Kd) for its affinity are 97.0 nM for CBX4 and CBX7, 850.0 nM for CDYL2, 910.0 nM for CDYL1b, and 6300.0 nM for CDY1. Additionally, UNC3866 shows cellular uptake with a concentration of 1.4 µM in human PC3 cells after 24 hours and has an antiproliferative activity with a GI50 value of 7600.0 nM. Bioactivity assessments using SPR and isothermal titration calorimetry have determined Kd values of 5600.0 nM and 910.0 nM for CDYL chromodomains. Moreover, UNC3866 exhibits modest antiviral activity by inhibiting SARS-CoV-2 3CL-Pro protease by 5.93% at 20 µM and reduces virus-induced cytotoxicity in VERO-6 cells by 0.19% at a concentration of 10 µM after 48 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	UNC3866 is a potent antagonist of the CBX7-H3 interaction, as determined by AlphaScreen.
Targets&IC50	CBX4 chromodomain:94 nM(Kd), CBX7 chromodomain:97 nM(Kd)

Chemical Properties

Molecular Weight	795.02
Formula	C₄₃H₆₆N₆O₈
Cas No.	1872382-47-2
Smiles	CCN(CC)CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)OC
Relative Density.	1.129 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 79.5 mg/mL (100 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2578 mL	6.2891 mL	12.5783 mL	62.8915 mL
5 mM	0.2516 mL	1.2578 mL	2.5157 mL	12.5783 mL
10 mM	0.1258 mL	0.6289 mL	1.2578 mL	6.2891 mL
20 mM	0.0629 mL	0.3145 mL	0.6289 mL	3.1446 mL
50 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2578 mL
100 mM	0.0126 mL	0.0629 mL	0.1258 mL	0.6289 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc