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Anti-Phospho-p53 (Ser20) Polyclonal Antibody

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Catalog No. TMAC-02982

Anti-Phospho-p53 (Ser20) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser20). Anti-Phospho-p53 (Ser20) Polyclonal Antibody can be used in WB.

Anti-Phospho-p53 (Ser20) Polyclonal Antibody

Anti-Phospho-p53 (Ser20) Polyclonal Antibody

😃Good
Catalog No. TMAC-02982
Anti-Phospho-p53 (Ser20) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser20). Anti-Phospho-p53 (Ser20) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2167-10 days
100 μL$3167-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-p53 (Ser20) Polyclonal Antibody is a Rabbit antibody targeting Phospho-p53 (Ser20). Anti-Phospho-p53 (Ser20) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human,Mouse
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundActs as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of Serine 20 (T-F-S(p)-D-L) derived from Human p53
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 53 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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