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Dantrolene sodium hemiheptahydrate

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Catalog No. T4054Cas No. 24868-20-0
Alias Sodium dantrolene, Dantrolene sodium salt, Dantrolene sodium hydrate, Dantrium

Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction. Dantrolene sodium hemiheptahydrate (Sodium dantrolene) is the sodium salt form of dantrolene, a hydantoin derivative, and direct-acting skeletal muscle relaxant.

Dantrolene sodium hemiheptahydrate
Other Forms of Dantrolene sodium hemiheptahydrate:

Dantrolene sodium hemiheptahydrate

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Purity: 99.72%
Catalog No. T4054Alias Sodium dantrolene, Dantrolene sodium salt, Dantrolene sodium hydrate, DantriumCas No. 24868-20-0
Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction. Dantrolene sodium hemiheptahydrate (Sodium dantrolene) is the sodium salt form of dantrolene, a hydantoin derivative, and direct-acting skeletal muscle relaxant.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
100 mg$30In StockIn Stock
500 mg$88In StockIn Stock
1 g$128In StockIn Stock
1 mL x 10 mM (in DMSO)$31In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.72%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1 and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction. Dantrolene sodium hemiheptahydrate (Sodium dantrolene) is the sodium salt form of dantrolene, a hydantoin derivative, and direct-acting skeletal muscle relaxant.
In vitro
Dantrolene sodium can inhibit intracellular Ca2+ release from the sarcoplasmic reticulum. In the linoleic acid emulsion system, Dantrolene sodium has strong antioxidant activity.
In vivo
In contrast of the slow soleus (SOL) muscle, Dantrolene sodium (5 mg/kg) has a greater inhibitory on the twitch contraction of the fast extensor digitorum longus (EDL) muscle.
SynonymsSodium dantrolene, Dantrolene sodium salt, Dantrolene sodium hydrate, Dantrium
Chemical Properties
Molecular Weight399.29
FormulaC14H9N4NaO5·3.5H2O
Cas No.24868-20-0
SmilesO.O.O.O.O.O.O.[NaH].[NaH].[O-][N+](=O)c1ccc(cc1)-c1ccc(C=NN2CC(=O)NC2=O)o1.[O-][N+](=O)c1ccc(cc1)-c1ccc(C=NN2CC(=O)NC2=O)o1
Relative Density.no data available
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 16.67 mg/mL (41.75 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 0.5 mg/mL (1.25 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5044 mL12.5222 mL25.0445 mL125.2223 mL
5 mM0.5009 mL2.5044 mL5.0089 mL25.0445 mL
10 mM0.2504 mL1.2522 mL2.5044 mL12.5222 mL
20 mM0.1252 mL0.6261 mL1.2522 mL6.2611 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitDantrolene sodium HydrateDantrolene sodium hemiheptahydrateDantrolene sodiumCalciumChannelCalcium ChannelCa2+ channelsCa channelsAutophagy
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