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Anti-ITPR3 Polyclonal Antibody
Catalog No. TMAB-07847 Copy Product Info
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Anti-ITPR3 Polyclonal Antibody is a Rabbit antibody targeting ITPR3. Anti-ITPR3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-ITPR3 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-07847
Anti-ITPR3 Polyclonal Antibody is a Rabbit antibody targeting ITPR3. Anti-ITPR3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-ITPR3 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-ITPR3 Polyclonal Antibody is a Rabbit antibody targeting ITPR3. Anti-ITPR3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Chicken,Dog,Cow,Horse,Rabbit) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (ITPR3) Polyclonal Antibody, Unconjugated (TMAB-07847) at 1: 200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane. |
| Tissue Specificity | Expressed in intestinal crypt and villus epithelial cells. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver. |
| Immunogen | KLH conjugated synthetic peptide: human ITPR3 |
| Antigen Species | Human |
| Gene Name | ITPR3 |
| Gene ID | |
| Protein Name | Inositol 1, 4, 5-trisphosphate receptor type 3 |
| Uniprot ID | |
| Function | Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. |
| Molecular Weight | Theoretical: 294 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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