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Anti-CD4 Antibody-PE (2I64)
🥰Excellent
Catalog No. TMAY-00765P
Anti-CD4 Antibody-PE (2I64) is a PE-conjugated Mouse antibody targeting CD4. Anti-CD4 Antibody-PE (2I64) can be used in FCM.
Anti-CD4 Antibody-PE (2I64)
Anti-CD4 Antibody-PE (2I64)
🥰Excellent
Catalog No. TMAY-00765P
Anti-CD4 Antibody-PE (2I64) is a PE-conjugated Mouse antibody targeting CD4. Anti-CD4 Antibody-PE (2I64) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD4 Antibody-PE (2I64) is a PE-conjugated Mouse antibody targeting CD4. Anti-CD4 Antibody-PE (2I64) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 2I64 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD4 expression on human peripheral blood lymphocytes. Cells were stained with PE-conjugated anti-Human CD4 and FITC conjugated anti-Human CD3 (BD Pharmingen™ Cat. No. 555332). The dot plots were derived from events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | 1 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD4 (rh CD4; TMPY-01400; NP_000607.1; Met1-Trp390) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | T-cell surface glycoprotein CD4, is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen-presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen-presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/PerCP/FITC |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human CD4 protein (TMPY-01400) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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