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PU23

Name: PU23
Brand: TargetMol
SKU: T9982
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9982Cas No. 817635-93-1

PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).

PU23

🥰Excellent

Purity: 99.52%

Catalog No. T9982Cas No. 817635-93-1

PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$77	In Stock
25 mg	$166	In Stock
50 mg	$262	In Stock
100 mg	$388	In Stock
200 mg	$549	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Batch Information

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Purity:99.52%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).
In vitro	6-Mercaptopurine (6-MP) inhibits HEK293 and HEK293/MRP4 cells with IC50s of 2.81 and 14.11 μM, respectively. Combined with PU23, 6-MP inhibits these cells with IC50s of 1.84 and 6.06 μM. Preincubation of HEK293/MRP4 cells with PU 23 (50 μM) for 2 hours significantly increases the intracellular concentration of 6-MP [1].

Chemical Properties

Molecular Weight	425.52
Formula	C₂₁H₁₉N₃O₃S₂
Cas No.	817635-93-1
Smiles	O=C(NC(=S)Nc1ccc(cc1)S(=O)(=O)NCc1ccccc1)c1ccccc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (129.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3501 mL	11.7503 mL	23.5007 mL	117.5033 mL
5 mM	0.4700 mL	2.3501 mL	4.7001 mL	23.5007 mL
10 mM	0.2350 mL	1.1750 mL	2.3501 mL	11.7503 mL
20 mM	0.1175 mL	0.5875 mL	1.1750 mL	5.8752 mL
50 mM	0.0470 mL	0.2350 mL	0.4700 mL	2.3501 mL
100 mM	0.0235 mL	0.1175 mL	0.2350 mL	1.1750 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc