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Anti-Neuropilin-2 Antibody-HRP (8I785)
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Catalog No. TMAY-01077H
Alias Npn-2, Npn2, Np-2, Np2, neuropilin 2, 1110048P06Rik
Anti-Neuropilin-2 Antibody-HRP (8I785) is a HRP-conjugated Mouse antibody targeting Neuropilin-2. Anti-Neuropilin-2 Antibody-HRP (8I785) can be used in ELISA.
Anti-Neuropilin-2 Antibody-HRP (8I785)
Anti-Neuropilin-2 Antibody-HRP (8I785)
😃Good
Catalog No. TMAY-01077HAlias Npn-2, Npn2, Np-2, Np2, neuropilin 2, 1110048P06Rik
Anti-Neuropilin-2 Antibody-HRP (8I785) is a HRP-conjugated Mouse antibody targeting Neuropilin-2. Anti-Neuropilin-2 Antibody-HRP (8I785) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $292 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: ELISA Reactivity: Human |
| Alias | Npn-2, Npn2, Np-2, Np2, neuropilin 2, 1110048P06Rik |
| Ig Type | Mouse IgG1 |
| Clone | 8I785 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 0.1-1 μg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Neurophilin-2 extracellular domain (rhNRP2; TMPY-00892; Met1-Tyr855; NP_003863.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as the formation of small lymphatic vessels and capillaries. A recent study has identified NRP-2 as a polysialylation protein expressed in human dendritic cells and modulates DC-T Cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis, and metastasis. |
| Conjucates | HRP |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Protein: Human NRP2 / Neurophilin-2 protein (TMPY-00892) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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