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Anti-NMDAR2B Polyclonal Antibody
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Catalog No. TMAB-09527
Anti-NMDAR2B Polyclonal Antibody is a Rabbit antibody targeting NMDAR2B. Anti-NMDAR2B Polyclonal Antibody can be used in WB,ICC/IF,ELISA.
Anti-NMDAR2B Polyclonal Antibody
Anti-NMDAR2B Polyclonal Antibody
😃Good
Catalog No. TMAB-09527
Anti-NMDAR2B Polyclonal Antibody is a Rabbit antibody targeting NMDAR2B. Anti-NMDAR2B Polyclonal Antibody can be used in WB,ICC/IF,ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NMDAR2B Polyclonal Antibody is a Rabbit antibody targeting NMDAR2B. Anti-NMDAR2B Polyclonal Antibody can be used in WB,ICC/IF,ELISA. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat) |
| Application | |
| Recommended Dose | WB: 1:500-2000; ICC/IF: 1:50-200; ELISA: 1:1000-5000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. |
| Construction | Polyclonal Antibody |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human GRIN2B |
| Antigen Species | Human |
| Gene Name | GRIN2B |
| Gene ID | |
| Protein Name | Glutamate receptor ionotropic, NMDA 2B |
| Uniprot ID | |
| Function | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). |
| Molecular Weight | Theoretical: 166 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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