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Anti-Transferrin Receptor/TFRC Antibody (2Q331)
(Synonyms: TR, TFRC, TfR1, TFR, T9, sTfR, p90, CD71) Copy Product Info
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Synonyms: TR, TFRC, TfR1, TFR, T9, sTfR, p90, CD71
Catalog No. TMAH-01165 Copy Product Info
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Anti-Transferrin Receptor/TFRC Antibody (2Q331) is an antibody targeting Transferrin Receptor/TFRC. Anti-Transferrin Receptor/TFRC Antibody (2Q331) can be used in ELISA.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-Transferrin Receptor/TFRC Antibody (2Q331) is an antibody targeting Transferrin Receptor/TFRC. Anti-Transferrin Receptor/TFRC Antibody (2Q331) can be used in ELISA. |
| Synonyms | TR, TFRC, TfR1, TFR, T9, sTfR, p90, CD71 |
| Ig Type | Human IgG1 |
| Clone | 2Q331 |
| Reactivity | Human |
| Application | |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type II membrane protein. Melanosome.; [Transferrin receptor protein 1, serum form]: Secreted. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion. When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human TFRC Protein |
| Antigen Species | Human |
| Gene Name | TFRC |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Immunology, Metabolism, Stem cells |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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