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Anti-SIRT2 Antibody (4V247) is a Rabbit antibody targeting SIRT2. Anti-SIRT2 Antibody (4V247) can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $298 | 7-10 days | 7-10 days | |
| 100 μL | $496 | 7-10 days | 7-10 days |
| Description | Anti-SIRT2 Antibody (4V247) is a Rabbit antibody targeting SIRT2. Anti-SIRT2 Antibody (4V247) can be used in WB. |
| Synonyms | Sirtuin type 2, Sirtuin 2, Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae), SIRT2_HUMAN, SIRT 2, SIR2-like protein 2, SIR2L2, SIR2L, SIR2, S. cerevisiae, homolog-loke 2, Sir2 related protein type 2, SIR2 like protein 2, SIR2, Silent information regulator 2, Silencing information regulator 2 like, Regulatory protein SIR2 homolog 2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-2, NAD dependent deacetylase sirtuin 2, FLJ37491, FLJ35621 |
| Ig Type | IgG |
| Clone | 4V247 |
| Reactivity | Human,Rat |
| Verified Activity | 1. Western blot analysis of SIRT2 on human brain lysates using anti-SIRT2 antibody at 1/1,000 dilution. ![]() |
| Application | |
| Recommended Dose | WB: 1:1000-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in a NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT proteins may function via mono-ADP-ribosylation of proteins. SIRT2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 43 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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