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Tectorigenin

Name: Tectorigenin
Brand: TargetMol
SKU: T3488
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3488Cas No. 548-77-6

Alias Tectorigenine, 4',5,7-Trihydroxy-6-methoxyisoflavone

Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption.

Tectorigenin

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Purity: 99.97%

Catalog No. T3488Alias Tectorigenine, 4',5,7-Trihydroxy-6-methoxyisoflavoneCas No. 548-77-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$47	In Stock	In Stock
25 mg	$85	In Stock	In Stock
50 mg	$129	In Stock	In Stock
100 mg	$192	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.97%

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Tectorigenin AI Summary

Tectorigenin inhibits EGFR with an IC50 value of 3300.0 nM, indicating its bioactivity in targeting the epidermal growth factor receptor. It exhibits estrogenic activity in human MCF7 and T47D cells; specifically, it shows a stimulatory effect on MCF7 cell proliferation equivalent to 10 pM estradiol at 0.3 μM and to 100 pM estradiol at 1.0 μM concentration. In T47D cells, it has a stimulatory effect equivalent to 10 pM estradiol at 0.04 μM and to 100 pM estradiol at 0.5 μM. This suggests Tectorigenin may interact with estrogen receptors and modulate estrogenic responses. Additionally, it exhibits antiviral activity against Hepatitis B virus by inhibiting HBsAg secretion, with an IC50 value of 53900.0 nM. Despite its potency in other areas, it shows no significant inhibition of cow milk xanthine oxidase at a concentration of 50 μg/mL..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption.
Synonyms	Tectorigenine, 4',5,7-Trihydroxy-6-methoxyisoflavone

Chemical Properties

Molecular Weight	300.26
Formula	C₁₆H₁₂O₆
Cas No.	548-77-6
Smiles	COc1c(O)cc2occ(-c3ccc(O)cc3)c(=O)c2c1O
Relative Density.	1.512g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 123 mg/mL (409.64 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3304 mL	16.6522 mL	33.3045 mL	166.5223 mL
5 mM	0.6661 mL	3.3304 mL	6.6609 mL	33.3045 mL
10 mM	0.3330 mL	1.6652 mL	3.3304 mL	16.6522 mL
20 mM	0.1665 mL	0.8326 mL	1.6652 mL	8.3261 mL
50 mM	0.0666 mL	0.3330 mL	0.6661 mL	3.3304 mL
100 mM	0.0333 mL	0.1665 mL	0.3330 mL	1.6652 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc