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Vevorisertib
🥰Excellent
Catalog No. T38847Cas No. 1416775-46-6
Alias ARQ751, ARQ 751
Vevorisertib (ARQ 751) is an orally active, potent and selective pan-AKT serine/threonine kinase inhibitor with inhibitory effects on AKT1/AKT2/AKT3 and is commonly used in the study of solid tumors with PIK3CA/AKT/PTEN mutations, showing dose-dependent antitumor activity.
Vevorisertib
🥰Excellent
Purity: 99.14%
Catalog No. T38847Alias ARQ751, ARQ 751Cas No. 1416775-46-6
Vevorisertib (ARQ 751) is an orally active, potent and selective pan-AKT serine/threonine kinase inhibitor with inhibitory effects on AKT1/AKT2/AKT3 and is commonly used in the study of solid tumors with PIK3CA/AKT/PTEN mutations, showing dose-dependent antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $162 | In Stock | |
| 5 mg | $396 | In Stock | |
| 10 mg | $752 | In Stock | |
| 25 mg | $1,650 | In Stock | |
| 50 mg | $2,620 | In Stock |
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Purity:99.14%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Vevorisertib (ARQ 751) is an orally active, potent and selective pan-AKT serine/threonine kinase inhibitor with inhibitory effects on AKT1/AKT2/AKT3 and is commonly used in the study of solid tumors with PIK3CA/AKT/PTEN mutations, showing dose-dependent antitumor activity. |
| Targets&IC50 | Akt2:0.81 nM, Akt3:1.31 nM, Akt3:1.31 nM (IC50), Akt1:0.55 nM, Akt2:0.81 nM (IC50), Akt1:0.55 nM (IC50) |
| In vitro | Vevorisertib binds to wild-type AKT1 and mutant AKT1-E17K with Kd of 1.2 nM and 8.6 nM, respectively, and inhibits pAKT(S473) in 293T cells transiently transfected with AKT1-E17K.[4] |
| In vivo | Vevorisertib (10-120 mg/kg) has dose-dependent antitumor activity in AKT1-E17K mutant endometrial patient xenograft (PDX) models.[4] |
| Alias | ARQ751, ARQ 751 |
| Molecular Weight | 586.73 |
| Formula | C35H38N8O |
| Cas No. | 1416775-46-6 |
| Smiles | O=C(N(C)C1CCN(C2=CC=CC(=C2)C3=NC4=C(N=C(C5=CC=CN=C5N)N4C6=CC=C(C=C6)C7(N)CCC7)C=C3)CC1)C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 4.00 mg/mL (6.82 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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