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Indole-3-pyruvic acid

Name: Indole-3-pyruvic acid
Brand: TargetMol
SKU: T4939
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4939Cas No. 392-12-1

Alias 3-(3-Indolyl)-2-oxopropanoic acid

Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes.

Indole-3-pyruvic acid

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Purity: 99.21%

Catalog No. T4939Alias 3-(3-Indolyl)-2-oxopropanoic acidCas No. 392-12-1

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$41	In Stock	-
100 mg	$66	In Stock	-
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.21%

Color:White to Yellow

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COA HNMR HPLC

Product Introduction

Indole-3-pyruvic acid AI Summary

Indole-3-pyruvic acid exhibits multifaceted bioactivity across a variety of biological pathways and target assays. It shows significant inhibitory effects on the Menin-MLL interaction relevant to MLL-related leukemias, Human Jumonji Domain Containing 2E (JMJD2E), Aldehyde Dehydrogenase 1 (ALDH1A1), Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase), Giardia lamblia Fructose-1,6-bisphosphate Aldolase, and AmpC Beta-Lactamase. Additionally, it modulates lipid storage in Drosophila cells, enhances SMN2 splice variant expression, induces DNA re-replication in normal breast cells, and inhibits tau fibril formation associated with Alzheimer's disease. It also shows activity against enzymatic targets related to Peroxiredoxins, HPGD, JMJD2A-Tudor Domain, BAZ2B, Rango, HP1-beta Chromodomain, RanGTP, Polymerase Iota, Mammalian Selenoprotein Thioredoxin Reductase, and the malarial parasite plastid, while also inhibiting Pin1. Indole-3-pyruvic acid displays antiviral activity against SARS-CoV-2, evidenced by its ability to inhibit cytotoxicity induced by the virus in Caco-2 and VERO-6 cells at a concentration of 10 µM. The compound achieves an inhibition rate of 9.07% in Caco-2 cells and shows IC50 values greater than 20000 nM and 19952.62 nM in different VERO-6 cell assays. Despite these relatively high IC50 values, the compound demonstrates inhibition of SARS-CoV-2 3CL-Pro protease with a percentage of -0.775% at 20µM concentration. Furthermore, Indole-3-pyruvic acid inhibits HDAC6 activity by 20.32% in an enzymatic assay using a commercial peptide substrate. With a log P value of 1.59, Indole-3-pyruvic acid has moderate lipophilicity, suggesting its potential for interactions with cell membranes and lipid-based structures in biological systems, influencing its absorption, distribution, and overall bioactivity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmental changes.
Synonyms	3-(3-Indolyl)-2-oxopropanoic acid

Chemical Properties

Molecular Weight	203.19
Formula	C₁₁H₉NO₃
Cas No.	392-12-1
Smiles	OC(=O)C(=O)Cc1c[nH]c2ccccc12
Relative Density.	1.421 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252 mg/mL (1240.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (24.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9215 mL	24.6075 mL	49.2150 mL	246.0751 mL
5 mM	0.9843 mL	4.9215 mL	9.8430 mL	49.2150 mL
10 mM	0.4922 mL	2.4608 mL	4.9215 mL	24.6075 mL
20 mM	0.2461 mL	1.2304 mL	2.4608 mL	12.3038 mL
50 mM	0.0984 mL	0.4922 mL	0.9843 mL	4.9215 mL
100 mM	0.0492 mL	0.2461 mL	0.4922 mL	2.4608 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc