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SA09-Cu

Catalog No. T78987 CAS 155641-16-0

SA09-Cu is a potent, noncompetitive inhibitor of NDM-1, with an IC50 of 9.6 nM. It inactivates NDM-1 by oxidizing the enzyme's Zn(II)-thiolate site and resists reduction by bacterial intracellular thiols. SA09-Cu effectively restores Meropenem efficacy against various clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) and hampers the progression of carbapenem resistance [1].

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SA09-Cu, CAS 155641-16-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

SA09-Cu, at a concentration of 40 μg/mL administered over 24 hours, maintained the viability of Vero E6 and L929 mouse cells above 60% [1]. Furthermore, SA09-Cu displayed a dose-dependent inhibition of NDM-1 activity in viable cells (E. coli-BL21-NDM-1 and EC23) at concentrations ranging from 2 to 16 μg/mL over a 24-hour period [1]. However, SA09-Cu exhibited negligible or only slight antibacterial activity on its own (MIC≥64 μg/mL) [1].

Molecular Weight	364.03
Formula	C8H16CuN2O2S4
CAS No.	155641-16-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SA09-Cu 155641-16-0 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.