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Rilapladib

Name: Rilapladib
Brand: TargetMol
SKU: T16751
Price: 94 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16751Cas No. 412950-08-4

Alias SB 659032

Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2, IC50 = 230 pM) and acts as an antagonist of the platelet-activating factor receptor.

Rilapladib

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Purity: 99.92%

Catalog No. T16751Alias SB 659032Cas No. 412950-08-4

Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2, IC50 = 230 pM) and acts as an antagonist of the platelet-activating factor receptor.

Pack Size	Price	Availability
1 mg	$94	In Stock
5 mg	$239	In Stock
10 mg	$388	In Stock
25 mg	$596	In Stock
50 mg	$828	In Stock
100 mg	$1,230	In Stock
200 mg	$1,670	In Stock
1 mL x 10 mM (in DMSO)	$387	In Stock

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Batch Information

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Purity:99.92%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2, IC50 = 230 pM) and acts as an antagonist of the platelet-activating factor receptor.
Targets&IC50	Lp-PLA2:230 pM
In vitro	Rilapladib reduces the PAF biological activity and levels, thereby reducing Lp-PLA2 biosynthesis and preventing the possible adverse effects of Lp-PLA2 [2].
Synonyms	SB 659032

Chemical Properties

Molecular Weight	735.8
Formula	C₄₀H₃₈F₅N₃O₃S
Cas No.	412950-08-4
Smiles	COCCN1CCC(CC1)N(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c(SCc2cccc(F)c2F)cc(=O)c2ccccc12
Relative Density.	1.36g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 78 mg/mL (106 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3591 mL	6.7953 mL	13.5906 mL	67.9532 mL
5 mM	0.2718 mL	1.3591 mL	2.7181 mL	13.5906 mL
10 mM	0.1359 mL	0.6795 mL	1.3591 mL	6.7953 mL
20 mM	0.0680 mL	0.3398 mL	0.6795 mL	3.3977 mL
50 mM	0.0272 mL	0.1359 mL	0.2718 mL	1.3591 mL
100 mM	0.0136 mL	0.0680 mL	0.1359 mL	0.6795 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc