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Anti-CYP3A4 Antibody (8Y208)
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Catalog No. TMAB-04897
Anti-CYP3A4 Antibody (8Y208) is a Rabbit antibody targeting CYP3A4. Anti-CYP3A4 Antibody (8Y208) can be used in WB,IHC-P,IHC-Fr,IP,IF.
Anti-CYP3A4 Antibody (8Y208)
Anti-CYP3A4 Antibody (8Y208)
😃Good
Catalog No. TMAB-04897
Anti-CYP3A4 Antibody (8Y208) is a Rabbit antibody targeting CYP3A4. Anti-CYP3A4 Antibody (8Y208) can be used in WB,IHC-P,IHC-Fr,IP,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $150 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-CYP3A4 Antibody (8Y208) is a Rabbit antibody targeting CYP3A4. Anti-CYP3A4 Antibody (8Y208) can be used in WB,IHC-P,IHC-Fr,IP,IF. |
| Ig Type | IgG |
| Clone | 8Y208 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IP: 1:20-50; IF: 1:100-500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum, membrane bound. |
| Tissue Specificity | Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level). |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. |
| Immunogen | A synthesized peptide: human Cytochrome P450 3A4 |
| Antigen Species | Human |
| Gene Name | CYP3A4 |
| Gene ID | |
| Protein Name | Cytochrome P450 3A4 |
| Uniprot ID | |
| Function | In animals, P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. Cytochrome P450 3A4 [human-3A1 Rat] is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin. |
| Molecular Weight | Theoretical: 57 kDa. Actual: 57 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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