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Bephenium (hydroxynaphthoate)

Name: Bephenium (hydroxynaphthoate)
Brand: TargetMol
SKU: T0286
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0286Cas No. 3818-50-6

Alias Bephenium Hydroxynaphthoate

Bephenium hydroxynaphthoate is a B-type AChR activator, formerly used in the treatment of hookworm infections and ascariasis.

Bephenium (hydroxynaphthoate)

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Purity: 99.87%

Catalog No. T0286Alias Bephenium HydroxynaphthoateCas No. 3818-50-6

Bephenium hydroxynaphthoate is a B-type AChR activator, formerly used in the treatment of hookworm infections and ascariasis.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bephenium (hydroxynaphthoate) AI Summary

Bephenium (hydroxynaphthoate) exhibits antiparasitic activity against Ancylostoma caninum isolates NT and PR, demonstrating varying potencies in different assays. In the force transduction assay, it has an EC50 of approximately 2.8 μM for both isolates, with a ratio of about 0.97. The IC50 values in the larval morphology assay are 45 μM for isolate NT and 17 μM for isolate PR, resulting in a ratio of 0.46. In the larval motility assay, the IC50 values are 19 μM for isolate NT and 8.6 μM for isolate PR, with a ratio of 0.45. The compound also exhibits antiviral activity against SARS-CoV-2, with an inhibition index of 0.4988 in Vero E6 cells after 72 hours and a hit score of 0.2695 against the USA-WA1/2020 strain in HRCE cells after 96 hours, indicating moderate efficacy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bephenium hydroxynaphthoate is a B-type AChR activator, formerly used in the treatment of hookworm infections and ascariasis.
Synonyms	Bephenium Hydroxynaphthoate

Chemical Properties

Molecular Weight	443.53
Formula	C₂₈H₂₉NO₄
Cas No.	3818-50-6
Smiles	Oc1cc2ccccc2cc1C([O-])=O.C[N+](C)(CCOc1ccccc1)Cc1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (56.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (5.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2546 mL	11.2732 mL	22.5464 mL	112.7319 mL
5 mM	0.4509 mL	2.2546 mL	4.5093 mL	22.5464 mL
10 mM	0.2255 mL	1.1273 mL	2.2546 mL	11.2732 mL
20 mM	0.1127 mL	0.5637 mL	1.1273 mL	5.6366 mL
50 mM	0.0451 mL	0.2255 mL	0.4509 mL	2.2546 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc