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GV-58

Name: GV-58
Brand: TargetMol
SKU: T11517
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11517Cas No. 1402821-41-3

GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.

GV-58

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Purity: 97.36%

Catalog No. T11517Cas No. 1402821-41-3

GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.

Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$147	In Stock
10 mg	$228	In Stock
25 mg	$455	In Stock
50 mg	$657	In Stock
100 mg	$918	In Stock
500 mg	$1,830	In Stock
1 mL x 10 mM (in DMSO)	$162	In Stock

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Purity:97.36%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.
Targets&IC50	Ca2+ channel, N-type:7.21 uM, Ca2+ channel, P/Q-type:8.81 uM
In vitro	In comparison with the parent molecule, (R)-roscovitine, GV-58 has a 20-fold less potent cyclin-dependent kinase antagonist effect, a 3- to 4-fold more potent Ca2+ channel agonist effect, and 4-fold higher efficacy as a Ca2+ channel agonist. GV-58 had no agonist activity (up to 100 μm) on the L-type α-subunit we tested (Cav1.3).

Chemical Properties

Molecular Weight	374.5
Formula	C₁₈H₂₆N₆OS
Cas No.	1402821-41-3
Smiles	CCCn1cnc2c(NCc3ccc(C)s3)nc(N[C@H](CC)CO)nc12
Relative Density.	1.33 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (240.32 mM), Sonication is recommended.

Methanol: 55 mg/mL (146.86 mM), Sonication is recommended.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6702 mL	13.3511 mL	26.7023 mL	133.5113 mL
5 mM	0.5340 mL	2.6702 mL	5.3405 mL	26.7023 mL
10 mM	0.2670 mL	1.3351 mL	2.6702 mL	13.3511 mL
20 mM	0.1335 mL	0.6676 mL	1.3351 mL	6.6756 mL
50 mM	0.0534 mL	0.2670 mL	0.5340 mL	2.6702 mL
100 mM	0.0267 mL	0.1335 mL	0.2670 mL	1.3351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc