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Hirsuteine

🥰Excellent
Catalog No. TN1081Cas No. 35467-43-7

Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.

Hirsuteine

Hirsuteine

🥰Excellent
Purity: 99.83%
Catalog No. TN1081Cas No. 35467-43-7
Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$52In StockIn Stock
5 mg$129In StockIn Stock
10 mg$197In StockIn Stock
25 mg$332In StockIn Stock
50 mgPreferentialIn StockIn Stock
1 mL x 10 mM (in DMSO)$139In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.83%
Appearance:Solid
Color:White to Yellow
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.
In vitro
Hirsuteine (300 nM-10 microM) inhibited dopamine release evoked by 100 microM nicotine in a concentration-dependent manner. Hirsuteine did not produce a parallel shift of the concentration-response relationship curve for nicotine, but reduced maximal dopamine release. Dopamine release evoked by 60 and 155 mM KCl was also inhibited by Hirsuteine, but the concentration necessary for significant inhibition was higher (more than 10 microM). Under whole cell voltage-clamp, Hirsuteine reversibly inhibited inward currents activated by 100 microM nicotine. The current inhibition was slightly accelerated by hyperpolarization[1]
Chemical Properties
Molecular Weight366.45
FormulaC22H26N2O3
Cas No.35467-43-7
Smiles[H][C@]12C[C@@H]([C@H](CN1CCc1c2[nH]c2ccccc12)C=C)C(=C/OC)\C(=O)OC
Relative Density.1.22 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (150.09 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7289 mL13.6444 mL27.2889 mL136.4443 mL
5 mM0.5458 mL2.7289 mL5.4578 mL27.2889 mL
10 mM0.2729 mL1.3644 mL2.7289 mL13.6444 mL
20 mM0.1364 mL0.6822 mL1.3644 mL6.8222 mL
50 mM0.0546 mL0.2729 mL0.5458 mL2.7289 mL
100 mM0.0273 mL0.1364 mL0.2729 mL1.3644 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitHirsuteineDopamineReceptorDopamine ReceptorDopamine
Related Tags: buy Hirsuteine | purchase Hirsuteine | Hirsuteine cost | order Hirsuteine | Hirsuteine chemical structure | Hirsuteine in vitro | Hirsuteine formula | Hirsuteine molecular weight
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