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Hydroxy-α-sanshool

🥰Excellent
Catalog No. T8307Cas No. 83883-10-7
Alias Hydroxy-​α-​sanshool

Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).

Hydroxy-α-sanshool

Hydroxy-α-sanshool

🥰Excellent
Purity: 99.47%
Catalog No. T8307Alias Hydroxy-​α-​sanshoolCas No. 83883-10-7
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$68In StockIn Stock
5 mg$163In StockIn Stock
10 mg$263In StockIn Stock
25 mg$446In StockIn Stock
50 mg$645In StockIn Stock
100 mg$886In StockIn Stock
1 mL x 10 mM (in DMSO)$179In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.47%
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Product Introduction

Bioactivity
Description
Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
Targets&IC50
TRPA1:69 µM (EC50), TRPV1:1.1 µM (EC50)
SynonymsHydroxy-​α-​sanshool
Chemical Properties
Molecular Weight263.38
FormulaC16H25NO2
Cas No.83883-10-7
SmilesC\C=C\C=C\C=C/CC\C=C\C(=O)NCC(C)(C)O
Relative Density.0.973 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 37.5 mg/mL (142.38 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7968 mL18.9840 mL37.9680 mL189.8398 mL
5 mM0.7594 mL3.7968 mL7.5936 mL37.9680 mL
10 mM0.3797 mL1.8984 mL3.7968 mL18.9840 mL
20 mM0.1898 mL0.9492 mL1.8984 mL9.4920 mL
50 mM0.0759 mL0.3797 mL0.7594 mL3.7968 mL
100 mM0.0380 mL0.1898 mL0.3797 mL1.8984 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

TRPVChannelTRPV1TRPV ChannelTRPChannelTRPA1TRP ChannelTransient receptor potential channelsInhibitorinhibitHydroxy-α-sanshoolHydroxyαsanshoolHydroxy-a-sanshoolHydroxy-alpha-sanshoolHydroxy α sanshoolEndogenousMetaboliteEndogenous Metabolite
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