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Hydroxy-α-sanshool

Name: Hydroxy-α-sanshool
Brand: TargetMol
SKU: T8307
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8307Cas No. 83883-10-7

Alias Hydroxy-α-sanshool

Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).

Hydroxy-α-sanshool

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Purity: 99.47%

Catalog No. T8307Alias Hydroxy-α-sanshoolCas No. 83883-10-7

Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$446	In Stock	In Stock
50 mg	$645	In Stock	In Stock
100 mg	$886	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.47%

Color:White to Yellow

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Product Introduction

Hydroxy-α-sanshool AI Summary

Hydroxy-α-sanshool activates the TRPA1 channel with an EC50 of 6600.0 nM and the TRPV1 channel with an EC50 of 1100.0 nM. It exhibits significant bioactivities related to growth inhibition and cytotoxicity against mouse Nf1-/-;Trp53-/- KR158 cells, showing a growth inhibition rate of 53.0% and a cytotoxicity activity of 106.0% at 2 μg/ml after 2 days. Hydroxy-α-sanshool also displays high selectivity for the human CB1 receptor over the human CB2 receptor, with a selectivity ratio IC50 of 1254.0. It demonstrates a 29.0% inhibition of both human CB1 and CB2 receptor internalization in CHO cells and effectively displaces [3H]-CP55940 from the human CB2 receptor with an IC50 of 59.0 nM. Additionally, it displaces [3H]-Win55212-2 from the human CB1 receptor with an IC50 of 7400.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hydroxy-α-sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).
Targets&IC50	TRPV1:1.1 µM (EC50), TRPA1:69 µM (EC50)
Synonyms	Hydroxy-α-sanshool

Chemical Properties

Molecular Weight	263.38
Formula	C₁₆H₂₅NO₂
Cas No.	83883-10-7
Smiles	C\C=C\C=C\C=C/CC\C=C\C(=O)NCC(C)(C)O
Relative Density.	0.973 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 37.5 mg/mL (142.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (7.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7968 mL	18.9840 mL	37.9680 mL	189.8398 mL
5 mM	0.7594 mL	3.7968 mL	7.5936 mL	37.9680 mL
10 mM	0.3797 mL	1.8984 mL	3.7968 mL	18.9840 mL
20 mM	0.1898 mL	0.9492 mL	1.8984 mL	9.4920 mL
50 mM	0.0759 mL	0.3797 mL	0.7594 mL	3.7968 mL
100 mM	0.0380 mL	0.1898 mL	0.3797 mL	1.8984 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc